TY - JOUR
T1 - Vitamin D receptor polymorphisms and growth until adulthood after very premature birth
AU - Finken, Martijn J. J.
AU - Schrevel, Marlies
AU - Houwing-Duistermaat, Jeanine J.
AU - Kharagjitsingh, Aan V.
AU - Dekker, Friedo W.
AU - Koeleman, Bobby P.
AU - Roep, Bart O.
AU - Wit, Jan M.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The accretion of bone mass is often impaired in preterm infants, which may contribute to postnatal growth failure. We tested the effects of the vitamin D receptor single-nucleotide polymorphisms (SNPs) c1521g, Fok1, Bsm1, and Taq1 on linear growth up until adulthood in 341 subjects born very prematurely (i.e., <32 weeks of gestation) from the Dutch Project On Preterm and Small-for-gestational-age infants cohort. The GG genotype of the c1521g SNP was associated with a 0.36 [95 % confidence interval (CI), 0.02–0.69] SD taller adult stature and the ff genotype of the Fok1 SNP with a 0.38 SD (95 % CI, 0.02–0.75) taller adult stature. Interaction between these genotypes on stature was observed from the age of 1 year onward (albeit nonsignificantly before the age of 5 years), with adult height being 1.54 (95 % CI, 0.44–2.63) SD taller in subjects carrying both genotypes. The Bsm1 and Taq1 variants were both associated with faster catch-up growth until 2 years of age. Statistical correction for potential confounders did not change our results. We conclude that homozygosity for the minor alleles of both c1521g and Fok1 is associated with a taller adult stature in subjects born very prematurely. The minor alleles of Bsm1 and Taq1 are associated with faster catch-up growth in infancy.
AB - The accretion of bone mass is often impaired in preterm infants, which may contribute to postnatal growth failure. We tested the effects of the vitamin D receptor single-nucleotide polymorphisms (SNPs) c1521g, Fok1, Bsm1, and Taq1 on linear growth up until adulthood in 341 subjects born very prematurely (i.e., <32 weeks of gestation) from the Dutch Project On Preterm and Small-for-gestational-age infants cohort. The GG genotype of the c1521g SNP was associated with a 0.36 [95 % confidence interval (CI), 0.02–0.69] SD taller adult stature and the ff genotype of the Fok1 SNP with a 0.38 SD (95 % CI, 0.02–0.75) taller adult stature. Interaction between these genotypes on stature was observed from the age of 1 year onward (albeit nonsignificantly before the age of 5 years), with adult height being 1.54 (95 % CI, 0.44–2.63) SD taller in subjects carrying both genotypes. The Bsm1 and Taq1 variants were both associated with faster catch-up growth until 2 years of age. Statistical correction for potential confounders did not change our results. We conclude that homozygosity for the minor alleles of both c1521g and Fok1 is associated with a taller adult stature in subjects born very prematurely. The minor alleles of Bsm1 and Taq1 are associated with faster catch-up growth in infancy.
KW - Follow-up studies
KW - Growth
KW - Height
KW - Preterm birth
KW - Vitamin D receptor
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937839438&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/26212485
U2 - https://doi.org/10.1007/s00774-015-0697-8
DO - https://doi.org/10.1007/s00774-015-0697-8
M3 - Article
C2 - 26212485
SN - 0914-8779
VL - 34
SP - 564
EP - 570
JO - Journal of bone and mineral metabolism
JF - Journal of bone and mineral metabolism
IS - 5
ER -