Vluchtig erytheem na alcoholconsumptie

BACKGROUND: Transient erythema after alcohol consumption is a side effect of topical tacrolimus use. The clinical picture is characterised by itching, a burning sensation and erythema, often at the site where tacrolimus is applied. The erythema develops shortly after alcohol consumption and disappears after approximately 1 hour. CASE DESCRIPTION: We are describing a patient who used a 0.1% tacrolimus ointment for periocular eczema and in whom transient erythema developed around the eyes after alcohol consumption. CONCLUSION: The symptoms may be caused by the capsaicin-like effects of both tacrolimus and ethanol. Potential inhibition of aldehyde dehydrogenase by tacrolimus may also play a role. Prophylactic treatment with acetylsalicylic acid before alcohol consumption reduces the symptoms.