Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie

J. J. Oosterheert; M. J. M. Bonten; M. M. E. Schneider; E. Buskens; J. W. J. Lammers; W. N. M. Hustinx; M. H. H. Kramer; J. M. Prins; Ph Th J. Slee; K. Kaasjager; I. M. Hoepelman

Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie

J. J. Oosterheert, M. J. M. Bonten, M. M. E. Schneider, E. Buskens, J. W. J. Lammers, W. N. M. Hustinx, M. H. H. Kramer, J. M. Prins, Ph Th J. Slee, K. Kaasjager, I. M. Hoepelman

Research output: Contribution to journal › Article › Professional

Abstract

OBJECTIVE: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia. DESIGN: Multicentre randomised prospective trial with follow-up at 28 days. METHOD: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group). An intention-to-treat analysis was performed. The primary outcome measure was clinical cure. The length of hospital stay was a secondary outcome measure. RESULTS: Out of the 302 patients included in the trial, data was analysed from 265 patients. The mortality rate in the intervention group did not differ significantly from that of the control group (mean difference: 2%; 95% CI: -3-8). After 28 days, 83% of the patients in the intervention group and 85% in the control group were clinically cured (mean difference: 2%; 95% CI: -7-10). The length of hospital stay was 1.9 days shorter in the intervention group (95% CI: 0.6-3.2 days). CONCLUSION: An early switch from intravenous to oral antibiotics in patients admitted to hospital for severe community acquired pneumonia is safe and reduces the length of hospital stay by approximately 2 days

Original language	Dutch
Pages (from-to)	269-274
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	152
Issue number	5
Publication status	Published - 2008

Cite this

Oosterheert, J. J., Bonten, M. J. M., Schneider, M. M. E., Buskens, E., Lammers, J. W. J., Hustinx, W. N. M., Kramer, M. H. H., Prins, J. M., Slee, P. T. J., Kaasjager, K., & Hoepelman, I. M. (2008). Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie. Nederlands Tijdschrift voor Geneeskunde, 152(5), 269-274.

@article{2d7f3fbd3659490583800956467367bf,

title = "Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie",

abstract = "OBJECTIVE: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia. DESIGN: Multicentre randomised prospective trial with follow-up at 28 days. METHOD: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group). An intention-to-treat analysis was performed. The primary outcome measure was clinical cure. The length of hospital stay was a secondary outcome measure. RESULTS: Out of the 302 patients included in the trial, data was analysed from 265 patients. The mortality rate in the intervention group did not differ significantly from that of the control group (mean difference: 2%; 95% CI: -3-8). After 28 days, 83% of the patients in the intervention group and 85% in the control group were clinically cured (mean difference: 2%; 95% CI: -7-10). The length of hospital stay was 1.9 days shorter in the intervention group (95% CI: 0.6-3.2 days). CONCLUSION: An early switch from intravenous to oral antibiotics in patients admitted to hospital for severe community acquired pneumonia is safe and reduces the length of hospital stay by approximately 2 days",

author = "Oosterheert, {J. J.} and Bonten, {M. J. M.} and Schneider, {M. M. E.} and E. Buskens and Lammers, {J. W. J.} and Hustinx, {W. N. M.} and Kramer, {M. H. H.} and Prins, {J. M.} and Slee, {Ph Th J.} and K. Kaasjager and Hoepelman, {I. M.}",

year = "2008",

language = "Dutch",

volume = "152",

pages = "269--274",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Vereniging Nederlands Tijdschrift voor Geneeskunde",

number = "5",

}

Oosterheert, JJ, Bonten, MJM, Schneider, MME, Buskens, E, Lammers, JWJ, Hustinx, WNM, Kramer, MHH, Prins, JM, Slee, PTJ, Kaasjager, K & Hoepelman, IM 2008, 'Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie', Nederlands Tijdschrift voor Geneeskunde, vol. 152, no. 5, pp. 269-274.

Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie. / Oosterheert, J. J.; Bonten, M. J. M.; Schneider, M. M. E. et al.
In: Nederlands Tijdschrift voor Geneeskunde, Vol. 152, No. 5, 2008, p. 269-274.

Research output: Contribution to journal › Article › Professional

TY - JOUR

T1 - Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie

AU - Oosterheert, J. J.

AU - Bonten, M. J. M.

AU - Schneider, M. M. E.

AU - Buskens, E.

AU - Lammers, J. W. J.

AU - Hustinx, W. N. M.

AU - Kramer, M. H. H.

AU - Prins, J. M.

AU - Slee, Ph Th J.

AU - Kaasjager, K.

AU - Hoepelman, I. M.

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia. DESIGN: Multicentre randomised prospective trial with follow-up at 28 days. METHOD: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group). An intention-to-treat analysis was performed. The primary outcome measure was clinical cure. The length of hospital stay was a secondary outcome measure. RESULTS: Out of the 302 patients included in the trial, data was analysed from 265 patients. The mortality rate in the intervention group did not differ significantly from that of the control group (mean difference: 2%; 95% CI: -3-8). After 28 days, 83% of the patients in the intervention group and 85% in the control group were clinically cured (mean difference: 2%; 95% CI: -7-10). The length of hospital stay was 1.9 days shorter in the intervention group (95% CI: 0.6-3.2 days). CONCLUSION: An early switch from intravenous to oral antibiotics in patients admitted to hospital for severe community acquired pneumonia is safe and reduces the length of hospital stay by approximately 2 days

AB - OBJECTIVE: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia. DESIGN: Multicentre randomised prospective trial with follow-up at 28 days. METHOD: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group). An intention-to-treat analysis was performed. The primary outcome measure was clinical cure. The length of hospital stay was a secondary outcome measure. RESULTS: Out of the 302 patients included in the trial, data was analysed from 265 patients. The mortality rate in the intervention group did not differ significantly from that of the control group (mean difference: 2%; 95% CI: -3-8). After 28 days, 83% of the patients in the intervention group and 85% in the control group were clinically cured (mean difference: 2%; 95% CI: -7-10). The length of hospital stay was 1.9 days shorter in the intervention group (95% CI: 0.6-3.2 days). CONCLUSION: An early switch from intravenous to oral antibiotics in patients admitted to hospital for severe community acquired pneumonia is safe and reduces the length of hospital stay by approximately 2 days

M3 - Article

C2 - 18333542

SN - 0028-2162

VL - 152

SP - 269

EP - 274

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 5

ER -