Will a decrease of blood homocysteine by vitamin supplementation reduce the risk for vascular disease?

Several studies have demonstrated a relationship between blood homocysteine and arterial vascular disease. Furthermore blood homocysteine can he lowered by means of vitamin supplementation. However in studies on the relation between blood homocysteine and vascular disease, no clear difference in vitamin level between cases and controls could be observed. We discuss this finding and argue that this may indicate an objection to beneficial effects of vitamin supplementation with respect to vascular disease. Also a hypothetical explanation for this phenomenon is discussed.