Wnt Signaling in Cancer Stem Cell Biology

Felipe de Sousa E Melo, Louis Vermeulen

Research output: Contribution to journalReview articleAcademicpeer-review

183 Citations (Scopus)

Abstract

Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations that result in elevated Wnt pathway activity. More recently, it has become apparent that Wnt signaling levels identify stem-like tumor cells that are responsible for fueling tumor growth. As therapeutic targeting of these tumor stem cells is an intense area of investigation, a concise understanding on how Wnt activity relates to cancer stem cell traits is needed. This review attempts at summarizing the intricacies between Wnt signaling and cancer stem cell biology with a special emphasis on colorectal cancer
Original languageEnglish
Pages (from-to)60
JournalCancers
Volume8
Issue number7
DOIs
Publication statusPublished - 2016

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