TY - JOUR
T1 - Women of reproductive age living in the North of the Netherlands
T2 - Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort
AU - Peters, Lilian L.
AU - Groen, Henk
AU - Sijtsma, Anna
AU - Jansen, Danielle
AU - Hoek, Annemieke
N1 - Funding Information: The Lifelines-ROAHD cohort was initiated and funded by the Lifelines-ROAHD research group from the University Medical Center Groningen (the Netherlands) and the Midwifery Academy Amsterdam Groningen. LP (Department of Midwifery Science/Midwifery Academy Amsterdam Groningen), HG (Department of Epidemiology), DJ (Department of General Practice and Elderly Care Medicine), AH (Department of Obstetrics & Gynaecology) were responsible for the questionnaire design and data collection, this is close collaboration with AS from the Lifelines Office. LP performed the statistical data analyses and drafted the manuscript. HG reviewed the statistical analyses. All authors reviewed the manuscript critically and approved the final version. LLP accepted full responsibility of the work and/or conduct of the study, had access to the data, and controlled the decision to publish. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023/5/11
Y1 - 2023/5/11
N2 - PURPOSE: The Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort provides a uniquely detailed dataset allowing investigations of determinants of reproductive health as well as the influence of reproductive events on future health and disease of mother and child(ren). Lifelines-ROAHD cohort is embedded in the population-based Lifelines cohort study. PARTICIPANTS: In total, 5412 women of reproductive age (20-45 years) were included in the Lifelines-ROAHD cohort, in the period 2017-2018. FINDINGS TO DATE: In the population, 45.6% of the women indicated that they had a natural menstrual cycle. In total, 908 women (16.8%) consulted a healthcare provider for infertility; subsequently diagnosed fertility problems were anovulation (24.4%), male partner infertility problems (22.5%) or unexplained infertility (22.2%). Women underwent various consecutive assisted reproductive treatments, for example, ovulation induction (19.8%) or in vitro fertilisation (5.4%). In total, 2808 women experienced 6158 pregnancies and 5068 births. Adverse pregnancy outcomes were miscarriage (14.3%), ectopic pregnancy (0.9%) or termination of pregnancy or medical abortion (2.0 %). The modes of delivery were vaginal births (74.9%), instrumental vaginal births (11.9%), elective caesarean section (3.9%) and emergency caesarean section (9.3%). Birth outcomes were born alive at term (93.6%), born alive (very) pre-term (5.8%), stillbirth (0.316%) and neonatal death (0.197%). Additional data about 2660 most recent pregnancies showed that 19.9% of the women had irregular working hours. One year postpartum, women indicated adverse physical health issues in one or more domains, range 0.5%-12.5%. They also indicated adverse psychological health issues in one or more domains, range 0.7%-1.6%, and 1.6% experienced diminished sexual health. FUTURE PLANS: Due to the embedding of Lifelines-ROAHD cohort in the original Lifelines cohort, the women will be longitudinally followed. Additionally, we aim to collect data with a second online questionnaire aiming to complete women's reproductive histories, by collecting data about potential first and subsequent pregnancies conceived after the date of completion of baseline Lifelines-ROAHD cohort.
AB - PURPOSE: The Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort provides a uniquely detailed dataset allowing investigations of determinants of reproductive health as well as the influence of reproductive events on future health and disease of mother and child(ren). Lifelines-ROAHD cohort is embedded in the population-based Lifelines cohort study. PARTICIPANTS: In total, 5412 women of reproductive age (20-45 years) were included in the Lifelines-ROAHD cohort, in the period 2017-2018. FINDINGS TO DATE: In the population, 45.6% of the women indicated that they had a natural menstrual cycle. In total, 908 women (16.8%) consulted a healthcare provider for infertility; subsequently diagnosed fertility problems were anovulation (24.4%), male partner infertility problems (22.5%) or unexplained infertility (22.2%). Women underwent various consecutive assisted reproductive treatments, for example, ovulation induction (19.8%) or in vitro fertilisation (5.4%). In total, 2808 women experienced 6158 pregnancies and 5068 births. Adverse pregnancy outcomes were miscarriage (14.3%), ectopic pregnancy (0.9%) or termination of pregnancy or medical abortion (2.0 %). The modes of delivery were vaginal births (74.9%), instrumental vaginal births (11.9%), elective caesarean section (3.9%) and emergency caesarean section (9.3%). Birth outcomes were born alive at term (93.6%), born alive (very) pre-term (5.8%), stillbirth (0.316%) and neonatal death (0.197%). Additional data about 2660 most recent pregnancies showed that 19.9% of the women had irregular working hours. One year postpartum, women indicated adverse physical health issues in one or more domains, range 0.5%-12.5%. They also indicated adverse psychological health issues in one or more domains, range 0.7%-1.6%, and 1.6% experienced diminished sexual health. FUTURE PLANS: Due to the embedding of Lifelines-ROAHD cohort in the original Lifelines cohort, the women will be longitudinally followed. Additionally, we aim to collect data with a second online questionnaire aiming to complete women's reproductive histories, by collecting data about potential first and subsequent pregnancies conceived after the date of completion of baseline Lifelines-ROAHD cohort.
KW - epidemiology
KW - obstetrics
KW - reproductive medicine
KW - subfertility
UR - http://www.scopus.com/inward/record.url?scp=85159741651&partnerID=8YFLogxK
U2 - https://doi.org/10.1136/bmjopen-2022-063890
DO - https://doi.org/10.1136/bmjopen-2022-063890
M3 - Article
C2 - 37169493
SN - 2044-6055
VL - 13
SP - e063890
JO - BMJ Open
JF - BMJ Open
IS - 5
M1 - e063890
ER -