TY - JOUR
T1 - Work productivity and activity impairment in disorders of gut-brain interaction
T2 - Data from the Rome Foundation Global Epidemiology Study
AU - Frändemark, Åsa
AU - Törnblom, Hans
AU - Hreinsson, J. hann P. ll
AU - Andresen, Viola
AU - Benninga, Marc A.
AU - Corazziari, Enrico S.
AU - Fukudo, Shin
AU - Mulak, Agata
AU - Santos, Javier
AU - Sperber, Ami D.
AU - Bangdiwala, Shrikant I.
AU - Palsson, Olafur S.
AU - Simrén, Magnus
N1 - Funding Information: This study was conducted under the auspices of the Rome Foundation Research Institute. The study was funded, in part, by research grants from Ironwood, Shire, Allergan, and Takeda. The study in Israel was funded by Takeda‐Israel. None of the funders was involved in the planning, design, implementation, statistical analyses, or any other aspect of the study. Publisher Copyright: © 2023 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.
PY - 2023/7
Y1 - 2023/7
N2 - Background: Disorders of Gut-Brain Interaction (DGBI) are highly prevalent worldwide, but their effect on work productivity has not gained much attention. Aims and Methods: We aimed to compare work productivity and activity impairment (WPAI) in persons with and without DGBI in a large population-based cohort and identify factors independently associated with WPAI in subjects with DGBI. Data were collected from Germany, Israel, Italy, Japan, the Netherlands, Poland, Spain and Sweden via Internet surveys as part of the Rome Foundation Global Epidemiology Study. Apart from the Rome IV diagnostic questionnaire, questionnaires evaluating WPAI related to general health (WPAI:GH), psychological distress (PHQ-4), somatic symptom severity (PHQ-15) and other factors were assessed. Results: Of the 16,820 subjects, 7111 met the criteria for DGBI according to the Rome IV diagnostic questionnaire. Subjects with DGBI were younger (median (interquartile range) age 43 (31–58) vs. 47 (33–62)) and more often female (59.0% vs. 43.7%) compared to subjects without DGBI. Subjects with DGBI had higher absenteeism, presenteeism (poor work productivity due to illness), overall work impairment and activity impairment (p < 0.001) compared with subjects without. For subjects with DGBI affecting more than one anatomical region, WPAI was incrementally higher for each additional region. There were significant differences in WPAI for subjects with DGBI in different countries. Subjects from Sweden had the highest overall work impairment and from Poland the lowest. Using multiple linear regression, male sex, fatigue, psychological distress, somatic symptom severity and number of anatomical regions were independently associated with overall work impairment (p < 0.05 for all). Conclusion: In the general population, people with DGBI have substantial WPAI compared with those without DGBI. The reasons for these findings should be explored further, but having multiple DGBI, psychological distress, fatigue and somatic symptom severity seem to contribute to this impairment associated with DGBI.
AB - Background: Disorders of Gut-Brain Interaction (DGBI) are highly prevalent worldwide, but their effect on work productivity has not gained much attention. Aims and Methods: We aimed to compare work productivity and activity impairment (WPAI) in persons with and without DGBI in a large population-based cohort and identify factors independently associated with WPAI in subjects with DGBI. Data were collected from Germany, Israel, Italy, Japan, the Netherlands, Poland, Spain and Sweden via Internet surveys as part of the Rome Foundation Global Epidemiology Study. Apart from the Rome IV diagnostic questionnaire, questionnaires evaluating WPAI related to general health (WPAI:GH), psychological distress (PHQ-4), somatic symptom severity (PHQ-15) and other factors were assessed. Results: Of the 16,820 subjects, 7111 met the criteria for DGBI according to the Rome IV diagnostic questionnaire. Subjects with DGBI were younger (median (interquartile range) age 43 (31–58) vs. 47 (33–62)) and more often female (59.0% vs. 43.7%) compared to subjects without DGBI. Subjects with DGBI had higher absenteeism, presenteeism (poor work productivity due to illness), overall work impairment and activity impairment (p < 0.001) compared with subjects without. For subjects with DGBI affecting more than one anatomical region, WPAI was incrementally higher for each additional region. There were significant differences in WPAI for subjects with DGBI in different countries. Subjects from Sweden had the highest overall work impairment and from Poland the lowest. Using multiple linear regression, male sex, fatigue, psychological distress, somatic symptom severity and number of anatomical regions were independently associated with overall work impairment (p < 0.05 for all). Conclusion: In the general population, people with DGBI have substantial WPAI compared with those without DGBI. The reasons for these findings should be explored further, but having multiple DGBI, psychological distress, fatigue and somatic symptom severity seem to contribute to this impairment associated with DGBI.
KW - Rome Foundation
KW - Rome IV criteria
KW - activity impairment
KW - fatigue
KW - gut-brain axis
KW - psychological distress
KW - somatic symptom
KW - work productivity
UR - http://www.scopus.com/inward/record.url?scp=85161996199&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/ueg2.12425
DO - https://doi.org/10.1002/ueg2.12425
M3 - Article
C2 - 37332146
SN - 2050-6406
VL - 11
SP - 503
EP - 513
JO - United European gastroenterology journal
JF - United European gastroenterology journal
IS - 6
ER -