Research output per year
Research output per year
Personal profile
specialisation
Epigenetics
Research interests
Switching genes on or off and keeping them in that state involves packaging of the genome by wrapping it around histone proteins. Histones cary different chemical modifications that affect the packaging of DNA by epigenetic mechanisms. The Van Leeuwen lab, located at the Netherlands Cancer Institute, studies mechanisms and principles of epigenetic regulation using innovative proteomic, genetic, and genomics approaches.
Our current work focuses on
- developing novel barcode technologies to decode the fundamental principles of epigenetic regulation in yeast and human cells
- understanding the role of epigenetics in the immune system, with special interest in the histone methyltransferase DOT1L in differentiation and function in B and T cells in mouse models,
More information about our research, lab, and publications, see:
www.medischebiologie.nl/van-leeuwen-group/
www.nki.nl/divisions/gene-regulation/van-leeuwen-fr-group/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Location, conservation and biosynthesis of J, an unusual DNA base in African trypanosomes., Netherlands Cancer Institute
Award Date: 7 May 1998
External positions
Senior Group Leader, Netherlands Cancer Institute
2019 → …
Group Leader, Netherlands Cancer Institute
2010 → 2019
AVL Fellow, Netherlands Cancer Institute
2003 → 2010
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DOT1L regulates chromatin reorganization and gene expression during sperm differentiation
Blanco, M. L., el Khattabi, L., Gobé, C., Crespo, M., Coulée, M., de la Iglesia, A., Ialy-Radio, C. M., Lapoujade, C., Givelet, M., Delessard, M., Seller-Corona, I., Yamaguchi, K., Vernet, N., van Leeuwen, F., Lermine, A., Okada, Y., Daveau, R., Oliva, R., Fouchet, P., Ziyyat, A., & 2 others, 5 Jun 2023, In: EMBO reports. 24, 6, e56316.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
Brouwer, I., Kerklingh, E., van Leeuwen, F. & Lenstra, T. L., May 2023, In: Nature structural & molecular biology. 30, 5, p. 692-702 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
van Breugel, M. E., van Kruijsbergen, I., Mittal, C., Lieftink, C., Brouwer, I., van den Brand, T., Kluin, R. J. C., Hoekman, L., Menezes, R. X., van Welsem, T., Del Cortona, A., Malik, M., Beijersbergen, R. L., Lenstra, T. L., Verstrepen, K. J., Pugh, B. F. & van Leeuwen, F., 7 Dec 2023, In: Molecular Cell. 83, 23, p. 4205-4221.e9Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro
Kwesi-Maliepaard, E. M., Malik, M., van Welsem, T., van Doorn, R., Vermeer, M. H., Vlaming, H., Jacobs, H. & van Leeuwen, F., 8 Nov 2022, In: Frontiers in genetics. 13, 1032958.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability
Willemsen, L., Prange, K. H. M., Neele, A. E., van Roomen, C. P. A. A., Gijbels, M., Griffith, G. R., Toom, M. D., Beckers, L., Siebeler, R., Spann, N. J., Chen, H-J., Bosmans, L. A., Gorbatenko, A., van Wouw, S., Zelcer, N., Jacobs, H., van Leeuwen, F. & de Winther, M. P. J., 22 Nov 2022, In: Cell reports. 41, 8, 111703.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus)