Fred van Leeuwen

(Principal Investigator), Prof.

1991 …2023

Research activity per year

Personal profile



Research interests

Switching genes on or off and keeping them in that state involves packaging of the genome by wrapping it around histone proteins. Histones cary different chemical modifications that affect the packaging of DNA by epigenetic mechanisms. The Van Leeuwen lab, located at the Netherlands Cancer Institute, studies mechanisms and principles of epigenetic regulation using innovative proteomic, genetic, and genomics approaches.

Our current work focuses on

- developing novel barcode technologies to decode the fundamental principles of epigenetic regulation in yeast and human cells

- understanding the role of epigenetics in the immune system, with special interest in the histone methyltransferase DOT1L in differentiation and function in B and T cells in mouse models,

More information about our research, lab, and publications, see:


Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Location, conservation and biosynthesis of J, an unusual DNA base in African trypanosomes., Netherlands Cancer Institute

Award Date: 7 May 1998

External positions

Senior Group Leader, Netherlands Cancer Institute

2019 → …

Group Leader, Netherlands Cancer Institute


AVL Fellow, Netherlands Cancer Institute


Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or