Projects per year
Personal profile
Research interests
Vascular cell biology and diabetes
Macrophages in vascular disease
Nuclear hormone receptors; NR4A-subfamily: Nur77
NR4As in metabolism
LIM domain-only protein FHL2, co-regulator of Nur77, in atherosclerosis, coagulation and obesity.
Expertise: Cell culture of human vascular smooth muscle cells and mouse macrophages, atherosclerosis in dedicated mouse models, lentiviral infection of primary vascular cells, high-fat diet induced diabetes in mice.
Specialisation
Medical Cell Biochemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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de Vries C.J.M.: Nuclear Receptor Nur77 in Vascular Biology and Metabolism
Bossuyt, S. N. V., van Capelleveen, J. C., Jongkind, R. C., Koenis, D. S., van Loon, N. M., Malinova, T., Medzikovic, L., Otermin Rubio, I., van der Stoel, M. M., Tan, J. M. E., Tran, M. K., Wanga, S. A., de Vries, C. J., Huveneers, S., de Waard, V., Arkenbout, E. K., van Loenen, P. B. & Vos, M.
1/02/2007 → …
Project: Research
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Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., Van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. & de Vries, C. J., 21 Aug 2018, In: Cell Reports. 24, 8, p. 2127-2140.e7Research output: Contribution to journal › Article › Academic › peer-review
Open Access63 Citations (Scopus) -
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1 α and affect bone marrow homeostasis in mice and humans
Koenis, D. S., Medzikovic, L., Vos, M., Beldman, T. J., van Loenen, P. B., van Tiel, C. M., Hamers, A. A. J., Rubio, I. O., de Waard, V. & de Vries, C. J. M., 2018, In: Journal of biological chemistry. 293, 39, p. 15070-15083Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus) -
NR4A nuclear receptors are orphans but not lonesome
Kurakula, K., Koenis, D. S., van Tiel, C. M. & de Vries, C. J. M., Nov 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 11, p. 2543-2555 13 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access97 Citations (Scopus)