Costa Bachas

Research output

Research output per year 2008 2020 2022 2023 2024

• 23 Article
• 2 Review article
• 1 Meeting Abstract
• 1 Comment/Letter to the editor
• 2 More
  • 1 Letter
  • 1 Phd-Thesis - Research and graduation internal

Research output per year

Research output per year

Search results

• 2024

  Impact of hemodilution on flow cytometry based measurable residual disease assessment in acute myeloid leukemia

  Tettero, J. M., Heidinga, M. E., Mocking, T. R., Fransen, G., Kelder, A., Scholten, W. J., Snel, A. N., Ngai, L. L., Bachas, C., van de Loosdrecht, A. A., Ossenkoppele, G. J., de Leeuw, D. C., Cloos, J. & Janssen, J. J. W. M., Mar 2024, In: Leukemia. 38, 3, p. 630-639 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)
• 2023

  Analytical assay validation for acute myeloid leukemia measurable residual disease assessment by multiparametric flow cytometry

  Tettero, J. M., Dakappagari, N., Heidinga, M. E., Oussoren-Brockhoff, Y., Hanekamp, D., Pahuja, A., Burns, K., Kaur, P., Alfonso, Z., van der Velden, V. H. J., te Marvelde, J. G., Hobo, W., Slomp, J., Bachas, C., Kelder, A., Nguyen, K. & Cloos, J., Nov 2023, In: Cytometry Part B - Clinical Cytometry. 104, 6, p. 426-439 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Measurable residual disease-guided therapy in intermediate-risk acute myeloid leukemia patients is a valuable strategy in reducing allogeneic transplantation without negatively affecting survival

  Tettero, J. M., Ngai, L. L., Bachas, C., Breems, D. A., Fischer, T., Gjertsen, B. T., Gradowska, P., Griskevicius, L., Janssen, J. J. W. M., Juliusson, G., Maertens, J., Manz, M. G., Pabst, T., Passweg, J., Porkka, K., Valk, P. J. M., Löwenberg, B., Ossenkoppele, G. J. & Cloos, J., 1 Oct 2023, In: Haematologica. 108, 10, p. 2794-2798 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Merging and imputation of flow cytometry data: A critical assessment

  Mocking, T. R., Duetz, C., van Kuijk, B. J., Westers, T. M., Cloos, J. & Bachas, C., Oct 2023, In: Cytometry Part A. 103, 10, p. 818-829 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Prognostic Significance of Measurable Residual Disease Detection by Flow Cytometry in Autologous Stem Cell Apheresis Products in AML

  Tettero, J. M., Buisman, Y., Ngai, L. L., Bachas, C., Gjertsen, B. T., Kelder, A., van de Loosdrecht, A. A., Manz, M. G., Pabst, T., Scholten, W., Ossenkoppele, G. J., Cloos, J. & de Leeuw, D. C., 21 Dec 2023, In: HemaSphere. 7, 12, p. E981

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Prospective validation of the prognostic relevance of CD34+CD38– AML stem cell frequency in the HOVON-SAKK132 trial

  Ngai, L. L., Hanekamp, D., Janssen, F., Carbaat-Ham, J., Hofland, M. A. M. A., Fayed, M. M. H. E., Kelder, A., Oudshoorn-van Marsbergen, L., Scholten, W. J., Snel, A. N., Bachas, C., Tettero, J. M., Breems, D. A., Fischer, T., Gjertsen, B. T., Griškevičius, L., Juliusson, G., van de Loosdrecht, A. A., Maertens, J. A., Manz, M. G., & 10 othersPabst, T., Passweg, J. R., Porkka, K., Valk, P. J. M., Gradowska, P., Löwenberg, B., de Leeuw, D. C., Janssen, J. J. W. M., Ossenkoppele, G. J. & Cloos, J., 25 May 2023, In: Blood. 141, 21, p. 2657-2661 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2022

  Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication

  Hansen, Q., Bachas, C., Smit, L. & Cloos, J., 2022, In: Cancer Drug Resistance. 5, 2, p. 344-367 24 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Characterization of myelodysplastic syndromes hematopoietic stem and progenitor cells using mass cytometry

  Bachas, C., Duetz, C., van Spronsen, M. F., Verhoeff, J., Garcia Vallejo, J. J., Jansen, J. H., Cloos, J., Westers, T. M. & van de Loosdrecht, A. A., 15 Mar 2022, (E-pub ahead of print) In: Cytometry Part B - Clinical Cytometry.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Concordance in measurable residual disease result after first and second induction cycle in acute myeloid leukemia: An outcome- and cost-analysis

  Tettero, J. M., Al-Badri, W. K. W., Ngai, L. L., Bachas, C., Breems, D. A., van Elssen, C. H. M. J., Fischer, T., Gjertsen, B. T., van Gorkom, G. N. Y., Gradowska, P., Greuter, M. J. E., Griskevicius, L., Juliusson, G., Maertens, J., Manz, M. G., Pabst, T., Passweg, J., Porkka, K., Löwenberg, B., Ossenkoppele, G. J., & 2 othersJanssen, J. J. W. M. & Cloos, J., 10 Oct 2022, In: Frontiers in Oncology. 12, p. 999822 999822.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Erratum: Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party (HemaSphere (2022) 6:1 (e676) DOI: 10.1097/HS9.0000000000000676)

  Tettero, J. M., Freeman, S. D., Buecklein, V., Venditti, A., Maurillo, L., Kern, W., Walter, R. B., Wood, B. L., Roumier, C., Philippe, J., Denys, B., Jorgensen, J. L., Bene, M. C., Lacombe, F., Plesa, A., Guzman, M. L., Wierzbowska, A., Czyz, A., Ngai, L. L., Schwarzer, A., & 5 othersBachas, C., Cloos, J., Subklewe, M., Fuering-Buske, M. & Buccisano, F., 23 Mar 2022, In: HemaSphere. 6, 3, p. E703

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access

• Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party

  Tettero, J. M., Freeman, S., Buecklein, V., Venditti, A., Maurillo, L., Kern, W., Walter, R. B., Wood, B. L., Roumier, C., Philippé, J., Denys, B., Jorgensen, J. L., Bene, M. C., Lacombe, F., Plesa, A., Guzman, M. L., Wierzbowska, A., Czyz, A., Ngai, L. L., Schwarzer, A., & 5 othersBachas, C., Cloos, J., Subklewe, M., Fuering-Buske, M. & Buccisano, F., 22 Jan 2022, In: HemaSphere. 6, 1, p. e676

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  31 Citations (Scopus)
• 2021

  2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

  Heuser, M., Freeman, S. D., Ossenkoppele, G. J., Buccisano, F., Hourigan, C. S., Ngai, L. L., Tettero, J. M., Bachas, C., Baer, C., Béné, M-C., Bücklein, V., Czyz, A., Denys, B., Dillon, R., Feuring-Buske, M., Guzman, M. L., Haferlach, T., Han, L., Herzig, J. K., Jorgensen, J. L., & 25 othersKern, W., Konopleva, M. Y., Lacombe, F., Libura, M., Majchrzak, A., Maurillo, L., Ofran, Y., Philippe, J., Plesa, A., Preudhomme, C., Ravandi, F., Roumier, C., Subklewe, M., Thol, F., van de Loosdrecht, A. A., van der Reijden, B. A., Venditti, A., Wierzbowska, A., Valk, P. J. M., Wood, B. L., Walter, R. B., Thiede, C., Döhner, K., Roboz, G. J. & Cloos, J., 30 Dec 2021, In: Blood. 138, 26, p. 2753-2767 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  281 Citations (Scopus)

• Computational flow cytometry as a diagnostic tool in suspected-myelodysplastic syndromes

  Duetz, C., van Gassen, S., Westers, T. M., van Spronsen, M. F., Bachas, C., Saeys, Y. & van de Loosdrecht, A. A., Aug 2021, In: Cytometry Part A. 99, 8, p. 814-824 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)
• 2020

  Applicability and reproducibility of acute myeloid leukaemia stem cell assessment in a multi-centre setting

  Hanekamp, D., Snel, A. N., Kelder, A., Scholten, W. J., Khan, N., Metzner, M., Irno-Consalvo, M., Sugita, M., de Jong, A., Oude Alink, S., Eidhof, H., Wilhelm, M., Feuring-Buske, M., Slomp, J., van der Velden, V. H. J., Sonneveld, E., Guzman, M., Roboz, G. J., Buccisano, F., Vyas, P., & 5 othersFreeman, S., Bachas, C., Ossenkoppele, G. J., Schuurhuis, G. J. & Cloos, J., 1 Sept 2020, In: British journal of haematology. 190, 6, p. 891-900 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Computational analysis of flow cytometry data in hematological malignancies: future clinical practice?

  Duetz, C., Bachas, C., Westers, T. M. & van de Loosdrecht, A. A., 1 Mar 2020, In: Current opinion in oncology. 32, 2, p. 162-169 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  34 Citations (Scopus)

• Harnessing gene expression profiles for the identification of ex vivo drug response genes in pediatric acute myeloid leukemia

  Cucchi, D. G. J., Bachas, C., van den Heuvel-Eibrink, M. M., Arentsen-Peters, S. T. C. J. M., Kwidama, Z. J., Schuurhuis, G. J., Assaraf, Y. G., de Haas, V., Kaspers, G. J. L. & Cloos, J., May 2020, In: Cancers. 12, 5, 1247.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• Machine Learning-Based Flow Cytometry Diagnostics in Myelodysplastic Syndromes: Validation in the HOVON89 Clinical Trial (EudraCT 2008-002195-10)

  Duetz, C., Van Gassen, S., Westers, T. M., in 't Hout, F., Cremers, E., Alhan, C., Bachas, C., Van Spronsen, M. F., Visser-Wisselaar, H., Chitu, D., De Graaf, A. O., Jansen, J., Saeys, Y. & van de Loosdrecht, A., 5 Nov 2020, In: Blood. 136

  Research output: Contribution to journal › Meeting Abstract › Academic

• Re: Myeloblasts in normal bone marrows expressing leukaemia-associated immunophenotypes

  Hanekamp, D., Bachas, C., van de Loosdrecht, A., Ossenkoppele, G. & Cloos, J., Feb 2020, In: Pathology. 52, 2, p. 289-291 3 p.

  Research output: Contribution to journal › Letter › Academic › peer-review
  10 Citations (Scopus)

• TP53 mutations and relevance of expression of TP53 pathway genes in paediatric acute myeloid leukaemia

  Cucchi, D. G. J., Bachas, C., Klein, K., Huttenhuis, S., Zwaan, C. M., Ossenkoppele, G. J., Janssen, J. M. W. M., Kaspers, G. L. & Cloos, J., 1 Mar 2020, In: British journal of haematology. 188, 5, p. 736-739 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)
• 2019

  Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death

  van Harten, A. M., Buijze, M., van der Mast, R., Rooimans, M. A., Martens-de Kemp, S. R., Bachas, C., Brink, A., Stigter-van Walsum, M., Wolthuis, R. M. F. & Brakenhoff, R. H., 1 Jul 2019, In: Oncogenesis. 8, 7, 38.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  42 Citations (Scopus)
• 2018

  Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection

  Bachas, C., Hodzic, J., van der Mijn, J. C., Stoepker, C., Verheul, H. M. W., Wolthuis, R. M. F., Felley-Bosco, E., van Wieringen, W. N., van Beusechem, V. W., Brakenhoff, R. H. & de Menezes, R. X., 20 Aug 2018, In: BMC Bioinformatics. 19, 1, p. 301 12 p., 301.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)
• 2015

  Gene Expression Profiles Associated with Pediatric Relapsed AML

  Bachas, C., Schuurhuis, G. J., Zwaan, C. M., van den Heuvel-Eibrink, M. M., den Boer, M. L., De Bont, E. S. J. M., Kwidama, Z. J., Reinhardt, D., Creutzig, U., de Haas, V., Kaspers, G. J. L. & Cloos, J., 2015, In: PLOS ONE. 10, 4, e0121730.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)
• 2014

  Characterization of relapsed Acute Myeloid Leukemia

  Bachas, C., 2014

  Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

  Open Access

• Clinical relevance of molecular aberrations in paediatric acute myeloid leukaemia at first relapse

  Bachas, C., Schuurhuis, G. J., Reinhardt, D., Creutzig, U., Kwidama, Z. J., Zwaan, C. M., van den Heuvel-Eibrink, M. M., De Bont, E. S. J. M., Elitzur, S., Rizzari, C., de Haas, V., Zimmermann, M., Cloos, J. & Kaspers, G. J. L., 2014, In: British journal of haematology. 166, 6, p. 902-910

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)
• 2013

  Procedures for the expansion of CD14(+) precursors from acute myeloid leukemic cells to facilitate dendritic cell-based immunotherapy

  van den Ancker, W., Wijnands, P. G. J. B., Ruben, J. M., Westers, T. M., Punt, B., Bachas, C., Ravenshorst, N., van Wetering, S., Kruisbeek, A. M., Bontkes, H. J., Ossenkoppele, G. J., van de Loosdrecht, A. A. & de Gruijl, T. D., 2013, In: Immunotherapy. 5, 11, p. 1183-1190

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Scopus)
• 2012

  The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse

  Bachas, C., Schuurhuis, G. J., Assaraf, Y. G., Kwidama, Z. J., Kelder, A., Wouters, F., Snel, A. N., Kaspers, G. J. L. & Cloos, J., 2012, In: Leukemia. 26, 6, p. 1313-1320

  Research output: Contribution to journal › Article › Academic › peer-review
  78 Citations (Scopus)
• 2010

  High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine

  Bachas, C., Schuurhuis, G. J., Hollink, I. H. I. M., Kwidama, Z. J., Goemans, B. F., Zwaan, C. M., van den Heuvel-Eibrink, M., De Bont, E. S. J. M., Reinhardt, D., Creutzig, U., de Haas, V., Assaraf, Y. G., Kaspers, G. J. L. & Cloos, J., 2010, In: Blood. 116, 15, p. 2752-2758

  Research output: Contribution to journal › Article › Academic › peer-review
  54 Citations (Scopus)
• 2008

  Identification of a Small Subpopulation of Candidate Leukemia Initiating Cells in the Side Population (SP) of Patients with Acute Myeloid Leukemia

  van der Pol, M., Westra, A. H., Ossenkoppele, G. J., van Rhenen, A., Kelder, A., Zweegman, S., Moshaver, B., Schuurhuis, G. J., Bachas, C. & Terwijn, M., 3 Oct 2008, In: Stem Cells.

  Research output: Contribution to journal › Article › Academic › peer-review

• Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia

  Moshaver, B., van Rhenen, A., Kelder, A., van der Pol, M., Terwijn, M., Bachas, C., Westra, A. H., Ossenkoppele, G. J., Zweegman, S. & Schuurhuis, G. J., 2008, In: Stem Cells. 26, 12, p. 3059-3067

  Research output: Contribution to journal › Article › Academic › peer-review
  85 Citations (Scopus)