Projects per year
Personal profile
specialisation
Elga de Vries is a professor in Neuro-immunology and head of the Neuro-immunology research group within the department of Molecular Cell Biology and Immunology (MCBI) at the Amsterdam UMC. Her research focuses on the cross talk of the immune system and the brain and the barriers between them. Using state of the art techniques, she and her team aim to uncover in predominantly human in vitro systems, samples and post-mortem tissues such underlying mechanisms, with a focus on multiple sclerosis (MS) and Alzheimer’s disease.
Elga de Vries was trained in the field of neuroscience/neuro-immunology as a biomedical scientist at the University of Utrecht (1990-1995) and during her PhD at Leiden University (1990-1995) and post-doc (as Marie-Curie fellow; 1998-1999) at University College London. Since 2000 (2011 as full professor), she runs her Neuro-immunology research group at the MCBI. As a PI and co-PI, she manage(d) various projects of PhD students, post-docs and research technicians (supervision: 21 completed PhD projects, 9 ongoing PhD projects, 3 ongoing postdoc projects, 6 completed postdoc projects, 2 technicians). Her work is/has been funded by the Dutch MS Research Foundation, ZonMW, NWO (VIDI in 2004), Health Holland and the EU (i.e. Marie Cure ITN, IMI, H2020 program). Her work is internationally recognized by peers as evidenced by the high number of collaborative grants and invitations for keynote lectures. Her work is published in leading journals such as ACTA Neuropathologica, eLife, Nature Neuroscience and Fluids and Barriers of the CNS. Elga de Vries is also scientific director of the MSCA and task force member of the research program Neuro-infection and Neuro-inflammation of the research institute Amsterdam Neuroscience, in which her research is embedded. She also serves as president-elect of the International Brain Barrier Society (https://www.ibbsoc.org/) and as chair of BBBNedwork (http://www.bbbnedwork.nl/), and as an active member of the scientific advisory board of Alzheimer Nederland and of the editorial board of the journal Fluids and Barriers of the CNS.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Member scientific advisory board, BPRC, Rijswijk
1 Apr 2022 → 1 Apr 2025
Member scientific advisory board, Alzheimer Nederland, Amersfoort, Netherlands
1 Jan 2022 → 1 Jan 2025
Keywords
- R Medicine (General)
Collaborations and top research areas from the last five years
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CONNECT - Connecting the Blood-Brain Barrier to Cerebral Organoids
Nogueira Pinto, H. & de Vries, H.
15/11/2021 → …
Project: Research
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Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis
Rodríguez-Lorenzo, S., van Olst, L., Rodriguez-Mogeda, C., Kamermans, A., van der Pol, S. M. A., Rodríguez, E., Kooij, G. & de Vries, H. E., 2022, In: eLife. 11, e73849.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Breaching Brain Barriers: B Cell Migration in Multiple Sclerosis
Rodriguez-Mogeda, C., Rodríguez-Lorenzo, S., Attia, J., van Horssen, J., Witte, M. E. & de Vries, H. E., 7 Jun 2022, In: BIOMOLECULES. 12, 6, 800.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access4 Citations (Scopus) -
Age-associated systemic factors change central and peripheral immunity in adult male mice
van Olst, L., Kamermans, A., van der Pol, S. M. A., Rodríguez, E., Hulshof, L. A., van Dijk, R. E., Vonk, D. N., Schouten, M., Witte, M. E., de Vries, H. E. & Middeldorp, J., 1 Jul 2023, In: Brain, behavior, and immunity. 111, p. 395-411 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, F., Giudice, L., Väänänen, M-A., Downes, N., Korhonen, P., Choo, X. Y., Välimäki, N-N., Mäkinen, P., Korvenlaita, N., Rozemuller, A. J., de Vries, H. E., Polo, J., Turunen, T. A., Ylä-Herttuala, S., Hansen, T. B., Grubman, A., Kaikkonen, M. U. & Malm, T., 12 Oct 2023, (E-pub ahead of print) In: Alzheimer's & dementia : the journal of the Alzheimer's Association.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis
Broos, J. Y., Loonstra, F. C., de Ruiter, L. R. J., Gouda, M., Fung, W. H., Schoonheim, M. M., Heijink, M., Strijbis, E. M. M., Teunissen, C., Killestein, J., de Vries, H. E., Giera, M., Uitdehaag, B. M. J. & Kooij, G., 1 Aug 2023, In: Neurology. 101, 5, p. e533-e545Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus)
Activities
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Signalling at the Brain Barriers
Elga de Vries (Member of programme committee)
22 Sept 2022Activity: Participating in or organising an event › Organising a conference, workshop, ... › Academic
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Neurovascular events during Alzheimer’s disease
Elga de Vries (Invited speaker)
30 Jul 2022Activity: Talk or presentation › Invited talk › Academic
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Scientific highlights
Elga de Vries (Invited speaker)
26 Oct 2022Activity: Talk or presentation › Invited talk › Academic
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Immune events at the Brain Barriers
Elga de Vries (Keynote speaker)
7 Nov 2022Activity: Talk or presentation › Invited talk › Academic
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Immune events at the brain barriers
Elga de Vries (Keynote speaker)
30 Nov 2022Activity: Talk or presentation › Invited talk › Academic