Research output per year
Research output per year
Personal profile
specialisation
Medical Neuropsychology
Research interests
Martin Klein is a clinical neuropsychologist and professor in medical neuropsychology at the Amsterdam UMC and Vrije Universiteit Amsterdam in the Netherlands. His research, in close cooperation with the departments of neurology, neurosurgery, and radiation oncology, focuses on several aspects:
Neurocognitive Functioning and Quality of Life in high-grade glioma patients
Initially research focused on determining neurocognitive functioning and health-related quality of life of patients with brain tumors. This resulted in influential papers on neurocognitive functioning and health-related quality of life of high-grade glioma patients at the time of diagnosis, at follow-up, at the time of recurrence, and on the prognostic value of neurocognitive functioning.
Impact of Treatment on Low-Grade Glioma and Neurological Patients
Regarding low-grade glioma patients, and other neurological patients, studies on the impact of surgery, radiotherapy, and on epilepsy and antiepileptic drugs on neurocognitive functioning and health-related quality of life are ongoing. The effectiveness of cognitive rehabilitation in patients with focal seizures has been addressed in a number of studies.
Understanding Brain Mechanisms Underlying Neurological Symptoms
Currently research aims at determining the brain mechanisms underlying frequent symptoms (e.g., neurocognitive deficits, epilepsy, fatigue, depression), the prevention of treatment effects on neurocognitive functioning, and on behavioral or pharmaceutical symptom treatment in primary and metastatic brain tumor patients and in oncological patients undergoing neurotoxic treatments affecting brain functioning.
Activities
Within the European Organization for the Research and Treatment of Cancer (EORTC), Martin Klein is entrusted with the scientific management of cognitive assessments across approximately 90 participating centers in Europe, contributing significantly to the clinical trials initiated by the EORTC Brain Tumor Group.
In 2023, Martin Klein extended his expertise to the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), contributing to the global assessment and reporting of radiation exposure levels and their effects, and helping to establish protective measures based on these evaluations.
Awards
- Received the Tim & Tom Gullikson Foundation and Society for Neuro-Oncology Award for Excellence in Quality of Life Research in 2001
- Honored with the National Brain Tumor Foundation/Tug McGraw Foundation Caregiver Research Award in 2008
- Awarded the Excellence of Applied Neuro-Oncology in 2017
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort
van Dam, M., de Jong, B. A., Willemse, E. A. J., Nauta, I. M., Huiskamp, M., Klein, M., Moraal, B., de Geus-Driessen, S., Geurts, J. J. G., Uitdehaag, B. M. J., Teunissen, C. E. & Hulst, H. E., Aug 2023, In: Journal of neurology. 270, 8, p. 3851-3861 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Association between objective neurocognitive functioning and neurocognitive complaints in recurrent high-grade glioma: Longitudinal evidence of cognitive awareness from EORTC brain tumour trials
Caramanna, I., Reijneveld, J. C., van de Ven, P. M., van den Bent, M., Idbaih, A., Wick, W., Taphoorn, M. J. B., Dirven, L., Bottomley, A. & Klein, M., 1 Jun 2023, In: European Journal of Cancer. 186, p. 38-51 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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Cannabinoids to Improve Health-Related Quality of Life in Patients with Neurological or Oncological Disease: A Meta-Analysis
Belgers, V., Röttgering, J. G., Douw, L., Klein, M., Ket, J. C. F., van de Ven, P. M., Würdinger, T., van Linde, M. E., Niers, J. M., Weber, M., Olde Rikkert, M. G., Lopez-Sendon, J., Arrieta, O., Svendsen, K. B., Chagas, M. H. N., de Almeida, C. M. O., Kouwenhoven, M. C. M. & de Witt Hamer, P. C., 1 Feb 2023, In: Cannabis and cannabinoid research. 8, 1, p. 41-55 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis
de Roeck, L., Gillebert, C. L. R., van Aert, R. C. M., Vanmeenen, A., Klein, M., Taphoorn, M. J. B., Gehring, K., Lambrecht, M. & Sleurs, C., 1 Aug 2023, In: Neuro-oncology. 25, 8, p. 1395-1414 20 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus) -
Correction to: Healthcare utilization and costs among intracranial meningioma patients during long-term follow-up (Journal of Neuro-Oncology, (2023), 161, 2, (357-370), 10.1007/s11060-022-04223-0)
the Dutch Meningioma Consortium, Jan 2023, In: Journal of Neuro-Oncology. 161, 2, p. 371 1 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access