Research output per year
Research output per year
Personal profile
Research interests
Dendritic cells (DCs) bridge the gap between innate and adaptive immunity and are regarded as orchestrators of immunological responses. This makes them an interesting target for immunotherapies. Within the DC4Balance consortium, I am focusing on the development of DC-modulating vaccines for allergen immunotherapy. The goal of our research is to target DCs in vivo to reporgram the allergy-associated Th2 response. Therefore, we aim to compose a nanoparticle-based drug delivery system, containing the respective allergen in combination with an immunomodulative adjuvant to induce an antigen-specific regulatory T cell response.
specialisation
DC-based allergen immunotherapy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Plant-produced Der p 2-bearing bioparticles activate Th1/Treg-related activation patterns in dendritic cells irrespective of the allergic background
Busold, S., Aglas, L., Menage, C., Desgagnés, R. J., Faye, L., Fitchette, A-C., de Jong, E. C., Martel, C., Stigler, M., Catala-Stordeur, V., Tropper, G., Auger, L., Morel, B., Versteeg, S. A., Vézina, L-P., Gomord, V. R., Layhadi, J. A., Shamji, M., Geijtenbeek, T. B. H. & van Ree, R., Apr 2024, In: Clinical and experimental allergy. 54, 4, p. 300-303 4 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access -
Rewiring biology: Targeting dendritic cells to reset allergic disease
Busold, S., 2024, 200 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
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Toll-like receptor 4 and Syk kinase shape dendritic cell-induced immune activation to major house dust mite allergens
Busold, S., Akkerdaas, J. H., Zijlstra-Willems, E. M., van der Graaf, K., Tas, S. W., de Jong, E. C., van Ree, R. & Geijtenbeek, T. B. H., 2023, In: Frontiers in Medicine. 10, 1105538.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Fel d 1 surface expression on plant-made eBioparticles combines potent immune activation and hypoallergenicity
Busold, S., Aglas, L., Menage, C., Auger, L., Desgagnés, R. J., Faye, L., Fitchette, A-C., de Jong, E. C., Martel, C., Stigler, M., Catala-Stordeur, V., Tropper, G., Vézina, L-P., Gomord, V. R., Geijtenbeek, T. B. H. & van Ree, R., Oct 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 10, p. 3124-3126 3 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access5 Citations (Scopus) -
Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors
Busold, S., Nagy, N. A., Tas, S. W., van Ree, R., de Jong, E. C. & Geijtenbeek, T. B. H., 7 Feb 2020, In: Frontiers in immunology. 11, 134.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access26 Citations (Scopus)