Project Details
Description
Since lowering systemic risk factors can only prevent 35% of cardiovascular events, novel interventions are needed. Two approaches are being pursued:
1. Directly increasing vessel-wall resistance against atherogenic insults.
2. Identifying inflammation-modulating pathways to attenuate atherogenesis
With respect to the first, efforts are being made to target the endothelial glycocalyx as therapeutic target.
With respect to the second, HDL-increasing agents are being evaluated as novel targets to attenuate pro-inflammatory changes.
Themes: Metabolic Disorders, Cardiovascular Diseases
1. Directly increasing vessel-wall resistance against atherogenic insults.
2. Identifying inflammation-modulating pathways to attenuate atherogenesis
With respect to the first, efforts are being made to target the endothelial glycocalyx as therapeutic target.
With respect to the second, HDL-increasing agents are being evaluated as novel targets to attenuate pro-inflammatory changes.
Themes: Metabolic Disorders, Cardiovascular Diseases
| Status | Active |
|---|---|
| Effective start/end date | 1/01/2006 → … |