Projects per year
Our focus on research is on premature atherosclerosis.
Fifty percent of all individuals, whom die of cardiovascular disease, are older than 80 years of age. This means, that cardiovascular disease is a disease of older age. Whenever young individuals develop cardiovascular disease, for instance a myocardial infarction at the age of 40 years, this is very unusual. This is called premature atherosclerosis. Likely, this person will have accelerated atherosclerotic disease. Sometimes this occurs in several family member of one family, suggesting a genetic predisposition for accelerate atherosclerotic disease.
Our main focus is on unravelling the underlying mechanisms responsible for accelerate atherosclerosis from an epidemiological, genetic and basic science point of view. Secondly, we try to estimate the risk family members have for accelerated atherosclerosis, since due to their young age the standard risk models cannot be used.
For that matter we have developed a premature atherosclerosis family outpatient clinic, in which we counsel patients and family members on cause, treatment and risk of cardiovascular disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent eventsMulders, T. A., Meyer, Z., van der Donk, C., Kroon, A. A., Ferreira, I., Stehouwer, C. D. A. & Pinto-Sietsma, S-J., 2011, In: International journal of cardiology. 153, 1, p. 64-67
Research output: Contribution to journal › Article › Academic › peer-review16 Citations (Scopus)
Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment A Post Hoc Analysis From the St. Francis Heart StudyMulders, T. A., Sivapalaratnam, S., Stroes, E. S. G., Kastelein, J. J. P., Guerci, A. D. & Pinto-Sietsma, S-J., 2012, In: JACC. Cardiovascular imaging. 5, 3, p. 252-260
Research output: Contribution to journal › Article › Academic › peer-review30 Citations (Scopus)
Non-invasive assessment of microvascular dysfunction in families with premature coronary artery diseaseMulders, T. A., Nieuwdorp, M., Stroes, E. S., Vink, H. & Pinto-Sietsma, S-J., 2013, In: International journal of cardiology. 168, 5, p. 5026-5028
Research output: Contribution to journal › Comment/Letter to the editor › Academic30 Citations (Scopus)
Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complicationsvan Rijsingen, I. A. W., Bakker, A., Azim, D., Hermans-van Ast, J. F., van der Kooi, A. J., van Tintelen, J. P., van den Berg, M. P., Christiaans, I., Lekanne dit Deprez, R. H., Wilde, A. A. M., Zwinderman, A. H., Meijers, J. C. M., Grootemaat, A. E., Nieuwland, R., Pinto, Y. M. & Pinto-Sietsma, S-J., 2013, In: International journal of cardiology. 168, 1, p. 472-477
Research output: Contribution to journal › Article › Academic › peer-review31 Citations (Scopus)
Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*Sondermeijer, B. M., Bakker, A., Halliani, A., de Ronde, M. W. J., Marquart, A. A., Tijsen, A. J., Mulders, T. A., Kok, M. G. M., Battjes, S., Maiwald, S., Sivapalaratnam, S., Trip, M. D., Moerland, P. D., Meijers, J. C. M., Creemers, E. E. & Pinto-Sietsma, S. J., 2011, In: PLOS ONE. 6, 10, p. e25946 7 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access87 Citations (Scopus)