Projects per year
The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
Infection and inflammation. We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.
Neuromuscular disorders. Our neuromuscular centre is a NFU (Nederlandse federatie van universitaire medische centra) and ERN (European reference network) accredited center for neuromuscular diseases in general, and motor neuron disease (ALS), idiopathic inflammatory myopathy, poliomyelitis, hereditary neuropathies and inflammatory polyneuropathies in particular. Inflammatory diseases of peripheral nerves and muscles are the main focus of the neuromuscular research-line, within the research area neuro-infection and inflammation. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and idiopathic inflammatory myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. This research is patient-driven and translational. More specific, clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response. For the critical illness neuromyopathies early predictors for disease and outcome are sought.
Improving the diagnostic and therapeutic options available to these patients are thus the starting point. The prevention of nerve and muscle damage and the improvement of the regenerative capacity are some of the key areas for the near future.
Since the completion of my Neurology training in 2000 I have been working as a neurologist, with a special interest in neuromuscular diseases and neuroimmunology. In daily practice, I see patients with all kinds of neuromuscular disease, such as motor neuron disease, myopathies and neuropathies. My specific area of interest is idiopathic inflammatory myopathies (myositis). Other areas of expertise include hereditary neuropathies and limb girdle muscular dystrophies, neurological manifestations of sarcoidosis and various inflammatory neuropathies (GBS, MMN, vasculitis).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Chair Dutch Neuromuscular Centre
1 May 2018 → …
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van de Beek, D., Brouwer, M., Eftimov, F., van der Kooi, A., van Schaik, I., Verhamme, C., Bijlsma, M., Ferwerda, B., Valls Seron, M., Jaspers, V., Costerus, J., Dorresteijn, K., Fritz, D., Hoogland, I., Jim, K., Kasanmoentalib, E., Kloek, A., Koopmans, M., Kremer, P., Schoenmaker, N., van Veen, K., Vermeij, J., Westendorp, W., Westhoff, D., Zock, E. & Schut, E.
1/12/2010 → …
OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study): A protocol for a prospective diagnostic accuracy study of multimodality testing in patients suspected of a treatable idiopathic inflammatory myopathyWalter, H. A. W., Kamperman, R. G., Raaphorst, J., Verhamme, C., Koelman, J. H. T. M., Potters, W. V., Hemke, R., Smithuis, F. F., Aronica, E., van Leeuwen, E. M. M., Baars, P. A., de Visser, M., van Schaik, I. N., Bossuyt, P. M. M. & van der Kooi, A. J., 1 Dec 2021, In: BMJ Open. 11, 12, e053594.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access1 Citation (Scopus)
Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot studyLim, J., Eftimov, F., Verhamme, C., Brusse, E., Hoogendijk, J. E., Saris, C. G. J., Raaphorst, J., de Haan, R. J., van Schaik, I. N., Aronica, E., de Visser, M. & van der Kooi, A. J., 1 Apr 2021, In: Rheumatology (Oxford, England). 60, 4, p. 1784-1792 9 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access22 Citations (Scopus)
Pathophysiological Mechanisms and Treatment of Dermatomyositis and Immune Mediated Necrotizing Myopathies: A Focused ReviewKamperman, R. G., van der Kooi, A. J., de Visser, M., Aronica, E. & Raaphorst, J., 1 Apr 2022, In: International journal of molecular sciences. 23, 8, 4301.
Research output: Contribution to journal › Review article › Academic › peer-reviewOpen Access14 Citations (Scopus)
Dutch Myositis Network, 3 Aug 2022, In: Rheumatology (Oxford, England). 61, 8, p. 3420-3426 7 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access
Lim, J., 23 Mar 2022, 217 p.
Research output: PhD Thesis › Phd-Thesis - Research and graduation internalOpen Access