TY - JOUR
T1 - The Complexity of the Post-Burn Immune Response
T2 - An Overview of the Associated Local and Systemic Complications
AU - Korkmaz, H. Ibrahim
AU - Flokstra, Gwendolien
AU - Waasdorp, Maaike
AU - Pijpe, Anouk
AU - Papendorp, Stephan G.
AU - de Jong, Evelien
AU - Rustemeyer, Thomas
AU - Gibbs, Susan
AU - van Zuijlen, Paul P. M.
N1 - Funding Information: This research was funded by the Dutch Burns Foundation (DBF), Beverwijk, project 19.105. Publisher Copyright: © 2023 by the authors.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Burn injury induces a complex inflammatory response, both locally and systemically, and is not yet completely unravelled and understood. In order to enable the development of accurate treatment options, it is of paramount importance to fully understand post-burn immunology. Research in the last decades describes insights into the prolonged and excessive inflammatory response that could exist after both severe and milder burn trauma and that this response differs from that of none-burn acute trauma. Persistent activity of complement, acute phase proteins and pro- and anti-inflammatory mediators, changes in lymphocyte activity, activation of the stress response and infiltration of immune cells have all been related to post-burn local and systemic pathology. This “narrative” review explores the current state of knowledge, focusing on both the local and systemic immunology post-burn, and further questions how it is linked to the clinical outcome. Moreover, it illustrates the complexity of post-burn immunology and the existing gaps in knowledge on underlying mechanisms of burn pathology.
AB - Burn injury induces a complex inflammatory response, both locally and systemically, and is not yet completely unravelled and understood. In order to enable the development of accurate treatment options, it is of paramount importance to fully understand post-burn immunology. Research in the last decades describes insights into the prolonged and excessive inflammatory response that could exist after both severe and milder burn trauma and that this response differs from that of none-burn acute trauma. Persistent activity of complement, acute phase proteins and pro- and anti-inflammatory mediators, changes in lymphocyte activity, activation of the stress response and infiltration of immune cells have all been related to post-burn local and systemic pathology. This “narrative” review explores the current state of knowledge, focusing on both the local and systemic immunology post-burn, and further questions how it is linked to the clinical outcome. Moreover, it illustrates the complexity of post-burn immunology and the existing gaps in knowledge on underlying mechanisms of burn pathology.
KW - burn
KW - complexity
KW - immune response
KW - inflammation
UR - http://www.scopus.com/inward/record.url?scp=85147769132&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/cells12030345
DO - https://doi.org/10.3390/cells12030345
M3 - Review article
C2 - 36766687
SN - 2073-4409
VL - 12
SP - 345
JO - Cells
JF - Cells
IS - 3
M1 - 345
ER -