A genome-wide association study of self-rated health

Miriam A. Mosing; Karin J. H. Verweij; Sarah E. Medland; Jodie Painter; Scott D. Gordon; Andrew C. Heath; Pamela A. Madden; Grant W. Montgomery; Nicholas G. Martin; M. Bartels; J.M. Vink; M.H.M. de Moor; J.J. Hottenga; E.J.C. de Geus; J.H. Smit; G. Willemsen; B.W.J.H. Penninx; D.I. Boomsma

doi:https://doi.org/10.1375/twin.13.4.398

A genome-wide association study of self-rated health

Miriam A. Mosing, Karin J. H. Verweij, Sarah E. Medland, Jodie Painter, Scott D. Gordon, Andrew C. Heath, Pamela A. Madden, Grant W. Montgomery, Nicholas G. Martin, M. Bartels, J.M. Vink, M.H.M. de Moor, J.J. Hottenga, E.J.C. de Geus, J.H. Smit, G. Willemsen, B.W.J.H. Penninx, D.I. Boomsma

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Abstract

Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.

Original language	English
Pages (from-to)	398-403
Journal	Twin research and human genetics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1375/twin.13.4.398
Publication status	Published - 2010

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Mosing, M. A., Verweij, K. J. H., Medland, S. E., Painter, J., Gordon, S. D., Heath, A. C., Madden, P. A., Montgomery, G. W., Martin, N. G., Bartels, M., Vink, J. M., de Moor, M. H. M., Hottenga, J. J., de Geus, E. J. C., Smit, J. H., Willemsen, G., Penninx, B. W. J. H., & Boomsma, D. I. (2010). A genome-wide association study of self-rated health. Twin research and human genetics, 13(4), 398-403. https://doi.org/10.1375/twin.13.4.398

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title = "A genome-wide association study of self-rated health",

abstract = "Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.",

author = "Mosing, {Miriam A.} and Verweij, {Karin J. H.} and Medland, {Sarah E.} and Jodie Painter and Gordon, {Scott D.} and Heath, {Andrew C.} and Madden, {Pamela A.} and Montgomery, {Grant W.} and Martin, {Nicholas G.} and M. Bartels and J.M. Vink and {de Moor}, M.H.M. and J.J. Hottenga and {de Geus}, E.J.C. and J.H. Smit and G. Willemsen and B.W.J.H. Penninx and D.I. Boomsma",

year = "2010",

doi = "https://doi.org/10.1375/twin.13.4.398",

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Mosing, MA, Verweij, KJH, Medland, SE, Painter, J, Gordon, SD, Heath, AC, Madden, PA, Montgomery, GW, Martin, NG, Bartels, M, Vink, JM, de Moor, MHM, Hottenga, JJ, de Geus, EJC, Smit, JH, Willemsen, G, Penninx, BWJH & Boomsma, DI 2010, 'A genome-wide association study of self-rated health', Twin research and human genetics, vol. 13, no. 4, pp. 398-403. https://doi.org/10.1375/twin.13.4.398

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AU - Gordon, Scott D.

AU - Heath, Andrew C.

AU - Madden, Pamela A.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Bartels, M.

AU - Vink, J.M.

AU - de Moor, M.H.M.

AU - Hottenga, J.J.

AU - de Geus, E.J.C.

AU - Smit, J.H.

AU - Willemsen, G.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

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A genome-wide association study of self-rated health

Abstract

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