TY - JOUR
T1 - A new complimentary web-based tool for manual analysis of microcirculation videos: Validation of the Capillary Mapper against the current gold standard AVA 3.2
AU - Hessler, Michael
AU - Arnemann, Philip-Helge
AU - Zamit, Frédéric
AU - Seidel, Laura
AU - Kampmeier, Tim-Gerald
AU - Kathöfer, Ulrich
AU - Morelli, Andrea
AU - Ince, Can
AU - Rehberg, Sebastian W.
AU - Ertmer, Christian
PY - 2018
Y1 - 2018
N2 - Objective: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA 3.2 software (AVA; MicroVision Medical B.V., Amsterdam, The Netherlands), which is the current gold standard for analysis of microcirculation videos. Methods: A web-based software program was developed, which enables manual analysis of videos of the microcirculation to be carried out according to recommendations of the 2018 consensus conference. A set of 50 high quality microcirculation videos was analyzed with AVA and CM with respect to total vessel density, perfused vessel density, proportion of perfused vessels, and the microvascular flow index. Results: Comparison of the mean values derived from manual analysis with CM and AVA revealed no significant differences in microcirculatory variables. Analysis according to Bland and Altman revealed an acceptable bias between manual analysis with the CM and AVA for all variables tested with sufficient limits of agreement. The analysis of intraclass correlation showed “excellent” agreement for all microcirculatory variables analyzed. Conclusions: The newly developed CM was successfully validated for manual analyses of microcirculation videos against the current gold standard, the software AVA 3.2.
AB - Objective: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA 3.2 software (AVA; MicroVision Medical B.V., Amsterdam, The Netherlands), which is the current gold standard for analysis of microcirculation videos. Methods: A web-based software program was developed, which enables manual analysis of videos of the microcirculation to be carried out according to recommendations of the 2018 consensus conference. A set of 50 high quality microcirculation videos was analyzed with AVA and CM with respect to total vessel density, perfused vessel density, proportion of perfused vessels, and the microvascular flow index. Results: Comparison of the mean values derived from manual analysis with CM and AVA revealed no significant differences in microcirculatory variables. Analysis according to Bland and Altman revealed an acceptable bias between manual analysis with the CM and AVA for all variables tested with sufficient limits of agreement. The analysis of intraclass correlation showed “excellent” agreement for all microcirculatory variables analyzed. Conclusions: The newly developed CM was successfully validated for manual analyses of microcirculation videos against the current gold standard, the software AVA 3.2.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054569826&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30192423
U2 - https://doi.org/10.1111/micc.12505
DO - https://doi.org/10.1111/micc.12505
M3 - Article
C2 - 30192423
SN - 1073-9688
VL - 25
JO - Microcirculation (New York, N.Y.
JF - Microcirculation (New York, N.Y.
IS - 8
M1 - e12505
ER -