A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

B. W. Van Oosten; M. H.G. Rep; R. A.W. Van Lier; P. E.T. Scholten; B. M.E. Von Blomberg; K. W. Pflughaupt; H. P. Hartung; H. J. Adèr; C. H. Polman

doi:https://doi.org/10.1016/0165-5728(96)00019-7

A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

B. W. Van Oosten, M. H.G. Rep, R. A.W. Van Lier, P. E.T. Scholten, B. M.E. Von Blomberg, K. W. Pflughaupt, H. P. Hartung, H. J. Adèr, C. H. Polman

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Abstract

Multiple sclerosis is probably mainly mediated by T-helper 1 (T(H)l)-lymphocytes. T(H)1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Ontcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of T(H)1- and T(H)2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.

Original language	English
Pages (from-to)	49-55
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	66
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(96)00019-7
Publication status	Published - 1 Jan 1996

Keywords

multiple sclerosis
pentoxifylline
treatment
tumor necrosis factor-alpha

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Van Oosten, B. W., Rep, M. H. G., Van Lier, R. A. W., Scholten, P. E. T., Von Blomberg, B. M. E., Pflughaupt, K. W., Hartung, H. P., Adèr, H. J., & Polman, C. H. (1996). A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis. Journal of Neuroimmunology, 66(1-2), 49-55. https://doi.org/10.1016/0165-5728(96)00019-7

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title = "A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis",

abstract = "Multiple sclerosis is probably mainly mediated by T-helper 1 (T(H)l)-lymphocytes. T(H)1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Ontcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of T(H)1- and T(H)2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.",

keywords = "multiple sclerosis, pentoxifylline, treatment, tumor necrosis factor-alpha",

author = "{Van Oosten}, {B. W.} and Rep, {M. H.G.} and {Van Lier}, {R. A.W.} and Scholten, {P. E.T.} and {Von Blomberg}, {B. M.E.} and Pflughaupt, {K. W.} and Hartung, {H. P.} and Ad{\`e}r, {H. J.} and Polman, {C. H.}",

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Van Oosten, BW, Rep, MHG, Van Lier, RAW, Scholten, PET, Von Blomberg, BME, Pflughaupt, KW, Hartung, HP, Adèr, HJ & Polman, CH 1996, 'A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis', Journal of Neuroimmunology, vol. 66, no. 1-2, pp. 49-55. https://doi.org/10.1016/0165-5728(96)00019-7

TY - JOUR

T1 - A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

AU - Van Oosten, B. W.

AU - Rep, M. H.G.

AU - Van Lier, R. A.W.

AU - Scholten, P. E.T.

AU - Von Blomberg, B. M.E.

AU - Pflughaupt, K. W.

AU - Hartung, H. P.

AU - Adèr, H. J.

AU - Polman, C. H.

PY - 1996/1/1

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N2 - Multiple sclerosis is probably mainly mediated by T-helper 1 (T(H)l)-lymphocytes. T(H)1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Ontcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of T(H)1- and T(H)2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.

AB - Multiple sclerosis is probably mainly mediated by T-helper 1 (T(H)l)-lymphocytes. T(H)1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Ontcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of T(H)1- and T(H)2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.

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KW - pentoxifylline

KW - treatment

KW - tumor necrosis factor-alpha

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JO - Journal of Neuroimmunology

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A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

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Keywords

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