A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp, Lousin Moumdjian, Paul van Asch, Veronica Popescu, Menno Michiel Schoonheim, Martijn D. Steenwijk, Ellen Vanzeir, Bart van Wijmeersch, Jeroen J.G. Geurts, Peter Feys, Hanneke E. Hulst

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)


Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

Original languageEnglish
Pages (from-to)1594-1598
Number of pages5
Issue number12
Publication statusPublished - 1 Oct 2020


  • Multiple sclerosis
  • cognitive rehabilitation
  • default-mode network
  • endurance exercise
  • functional connectivity
  • hippocampus

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