TY - JOUR
T1 - A pilot study of the effects of running training on visuospatial memory in MS
T2 - A stronger functional embedding of the hippocampus in the default-mode network?
AU - Huiskamp, Marijn
AU - Moumdjian, Lousin
AU - van Asch, Paul
AU - Popescu, Veronica
AU - Schoonheim, Menno Michiel
AU - Steenwijk, Martijn D.
AU - Vanzeir, Ellen
AU - van Wijmeersch, Bart
AU - Geurts, Jeroen J.G.
AU - Feys, Peter
AU - Hulst, Hanneke E.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.
AB - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.
KW - Multiple sclerosis
KW - cognitive rehabilitation
KW - default-mode network
KW - endurance exercise
KW - functional connectivity
KW - hippocampus
UR - http://www.scopus.com/inward/record.url?scp=85070293639&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/1352458519863644
DO - https://doi.org/10.1177/1352458519863644
M3 - Article
C2 - 31317828
SN - 1352-4585
VL - 26
SP - 1594
EP - 1598
JO - MULTIPLE SCLEROSIS JOURNAL
JF - MULTIPLE SCLEROSIS JOURNAL
IS - 12
ER -