A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes)

H. ten Cate; B. E. Schenk; B. J. Biemond; M. [=Marcel M.] Levi; T. van der Poll; H. R. Buller; J. W. ten Cate

A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes)

H. ten Cate, B. E. Schenk, B. J. Biemond, M. [=Marcel M.] Levi, T. van der Poll, H. R. Buller, J. W. ten Cate

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Abstract

This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines

Original language	English
Pages (from-to)	280-284
Journal	Journal of medical primatology
Volume	23
Issue number	5
Publication status	Published - 1994

Cite this

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title = "A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes)",

abstract = "This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines",

author = "{ten Cate}, H. and Schenk, {B. E.} and Biemond, {B. J.} and Levi, {M. [=Marcel M.]} and {van der Poll}, T. and Buller, {H. R.} and {ten Cate}, {J. W.}",

year = "1994",

language = "English",

volume = "23",

pages = "280--284",

journal = "Journal of medical primatology",

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T1 - A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes)

AU - ten Cate, H.

AU - Schenk, B. E.

AU - Biemond, B. J.

AU - Levi, M. [=Marcel M.]

AU - van der Poll, T.

AU - Buller, H. R.

AU - ten Cate, J. W.

PY - 1994

Y1 - 1994

N2 - This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines

AB - This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines

M3 - Article

C2 - 7869356

SN - 0047-2565

VL - 23

SP - 280

EP - 284

JO - Journal of medical primatology

JF - Journal of medical primatology

IS - 5

ER -