TY - JOUR
T1 - A systematic review of the effectiveness of naltrexone in the maintenance treatment of opioid and alcohol dependence
AU - Roozen, Hendrik G.
AU - de Waart, Ranne
AU - van der Windt, Danielle A. W. M.
AU - van den Brink, Wim
AU - de Jong, Cor A. J.
AU - Kerkhof, Ad J. F. M.
AU - de Jong, C.G.W.
PY - 2006
Y1 - 2006
N2 - This systematic review summarises evidence of the effectiveness of naltrexone (NTX) and the added value of psychosocial treatment in the maintenance treatment of opioid and alcohol dependence. Studies were selected through a literature search conducted in March 2004. Seven opioid and seventeen alcohol studies were identified. When possible, meta-(regression) analyses were performed. There is lack of evidence about the effectiveness of NTX in the maintenance treatment of opioid dependence. There is evidence for the effectiveness and applicability of NTX in the management of alcohol dependence. The opioid studies combined NTX with a variety of psychosocial interventions, which plagued the evaluation of their value. Concomitant psychosocial interventions used in the alcohol studies were mainly cognitive behavioural, which seems to be more effective than NTX combined with supportive therapy. Available data do not allow firm conclusions regarding the added effect of psychosocial interventions. However, the data suggest that a combination of naltrexone with cognitive behavioural relapse prevention therapy is beneficial in alcohol dependent patients
AB - This systematic review summarises evidence of the effectiveness of naltrexone (NTX) and the added value of psychosocial treatment in the maintenance treatment of opioid and alcohol dependence. Studies were selected through a literature search conducted in March 2004. Seven opioid and seventeen alcohol studies were identified. When possible, meta-(regression) analyses were performed. There is lack of evidence about the effectiveness of NTX in the maintenance treatment of opioid dependence. There is evidence for the effectiveness and applicability of NTX in the management of alcohol dependence. The opioid studies combined NTX with a variety of psychosocial interventions, which plagued the evaluation of their value. Concomitant psychosocial interventions used in the alcohol studies were mainly cognitive behavioural, which seems to be more effective than NTX combined with supportive therapy. Available data do not allow firm conclusions regarding the added effect of psychosocial interventions. However, the data suggest that a combination of naltrexone with cognitive behavioural relapse prevention therapy is beneficial in alcohol dependent patients
U2 - https://doi.org/10.1016/j.euroneuro.2005.11.001
DO - https://doi.org/10.1016/j.euroneuro.2005.11.001
M3 - Review article
C2 - 16361086
SN - 0924-977X
VL - 16
SP - 311
EP - 323
JO - European neuropsychopharmacology
JF - European neuropsychopharmacology
IS - 5
ER -
