TY - JOUR
T1 - Additional Screening and Treatment of Malaria during Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers during the First Year of Life
AU - Natama, Hamtandi Magloire
AU - Rovira-Vallbona, Eduard
AU - Sorgho, Hermann
AU - Somé, M. Athanase
AU - Traoré-Coulibaly, Maminata
AU - Scott, Susana
AU - Zango, Serge Henri
AU - Sawadogo, Ousséni
AU - Zongo, Sibiri Claude
AU - Valéa, Innocent
AU - Mens, Petra F.
AU - Schallig, Henk D. F. H.
AU - Kestens, Luc
AU - Tinto, Halidou
AU - Rosanas-Urgell, Anna
PY - 2018
Y1 - 2018
N2 - Background Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants. Methods In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs. Results Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval,.55-0.99]; P =.047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed. Conclusions Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.
AB - Background Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants. Methods In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs. Results Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval,.55-0.99]; P =.047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed. Conclusions Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048142278&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29659897
U2 - https://doi.org/10.1093/infdis/jiy140
DO - https://doi.org/10.1093/infdis/jiy140
M3 - Article
C2 - 29659897
SN - 0022-1899
VL - 217
SP - 1967
EP - 1976
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 12
ER -