Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors

T. Fall; S. Hägg; A. Ploner; R. Mägi; K. Fischer; H.H.M. Draisma; A.-P. Sarin; B. Benyamin; C. Ladenvall; M. Akerlund; M. Kals; T. Esko; C.P. Nelson; M. Kaakinen; V. Huikari; M. Mangino; A. Meirhaeghe; K. Kristiansson; M.L. Nuotio; M. Kobl; H. Grallert; A. Dehghan; M. Kuningas; P.S. de Vries; R.F.A.G. de Bruijn; S.M. Willems; K. Heikkilä; K. Silventoinen; K.H. Pietilainen; V. Legry; V. Giedraitis; L. Goumidi; A.C. Syvänen; K. Strauch; W. Koenig; P. Lichtner; C. Herder; A. Palotie; C. Menni; A.G. Uitterlinden; K. Kuulasmaa; A.S. Havulinna; L.A. Moreno; M. Gonzalez-Gross; A. Evans; D.A. Tregouet; J.W. Yarnell; J. Virtamo; J. Ferrières; G. Veronesi; M. Perola; D. Arveiler; P. Brambilla; L. Lind; J. Kaprio; A. Hofman; B.H. Stricker; C.M. van Duijn; M. Arfan Ikram; O.H. Franco; D. Cottel; J. Dallongeville; A.S. Hall; A. Jula; M.D. Tobin; B.W.J.H. Penninx; A. Peters; C. Gieger; N.J. Samani; G.W. Montgomery; J.B. Whitfield; N.G. Martin; L. Groop; T.D. Spector; P.K. Magnusson; P. Amouyel; D.I. Boomsma; P.M. Nilsson; M.R. Järvelin; V. Lyssenko; A. Metspalu; D.P. Strachan; V. Salomaa; S. Ripatti; N.L. Pedersen; I. Prokopenko; M.I. McCarthy; E. Ingelsson

doi:https://doi.org/10.2337/db14-0988

Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors

T. Fall, S. Hägg, A. Ploner, R. Mägi, K. Fischer, H.H.M. Draisma, A.-P. Sarin, B. Benyamin, C. Ladenvall, M. Akerlund, M. Kals, T. Esko, C.P. Nelson, M. Kaakinen, V. Huikari, M. Mangino, A. Meirhaeghe, K. Kristiansson, M.L. Nuotio, M. KoblH. Grallert, A. Dehghan, M. Kuningas, P.S. de Vries, R.F.A.G. de Bruijn, S.M. Willems, K. Heikkilä, K. Silventoinen, K.H. Pietilainen, V. Legry, V. Giedraitis, L. Goumidi, A.C. Syvänen, K. Strauch, W. Koenig, P. Lichtner, C. Herder, A. Palotie, C. Menni, A.G. Uitterlinden, K. Kuulasmaa, A.S. Havulinna, L.A. Moreno, M. Gonzalez-Gross, A. Evans, D.A. Tregouet, J.W. Yarnell, J. Virtamo, J. Ferrières, G. Veronesi, M. Perola, D. Arveiler, P. Brambilla, L. Lind, J. Kaprio, A. Hofman, B.H. Stricker, C.M. van Duijn, M. Arfan Ikram, O.H. Franco, D. Cottel, J. Dallongeville, A.S. Hall, A. Jula, M.D. Tobin, B.W.J.H. Penninx, A. Peters, C. Gieger, N.J. Samani, G.W. Montgomery, J.B. Whitfield, N.G. Martin, L. Groop, T.D. Spector, P.K. Magnusson, P. Amouyel, D.I. Boomsma, P.M. Nilsson, M.R. Järvelin, V. Lyssenko, A. Metspalu, D.P. Strachan, V. Salomaa, S. Ripatti, N.L. Pedersen, I. Prokopenko, M.I. McCarthy, E. Ingelsson

Psychiatry (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 10

Original language	English
Pages (from-to)	1841-1852
Number of pages	12
Journal	Diabetes
Volume	64
Issue number	5
DOIs	https://doi.org/10.2337/db14-0988
Publication status	Published - 2015

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.2337/db14-0988

Cite this

Fall, T., Hägg, S., Ploner, A., Mägi, R., Fischer, K., Draisma, H. H. M., Sarin, A.-P., Benyamin, B., Ladenvall, C., Akerlund, M., Kals, M., Esko, T., Nelson, C. P., Kaakinen, M., Huikari, V., Mangino, M., Meirhaeghe, A., Kristiansson, K., Nuotio, M. L., ... Ingelsson, E. (2015). Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors. Diabetes, 64(5), 1841-1852. https://doi.org/10.2337/db14-0988

@article{1cf1569aa96a4eaab383bb62bfe69b09,

title = "Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors",

abstract = "Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 10",

author = "T. Fall and S. H{\"a}gg and A. Ploner and R. M{\"a}gi and K. Fischer and H.H.M. Draisma and A.-P. Sarin and B. Benyamin and C. Ladenvall and M. Akerlund and M. Kals and T. Esko and C.P. Nelson and M. Kaakinen and V. Huikari and M. Mangino and A. Meirhaeghe and K. Kristiansson and M.L. Nuotio and M. Kobl and H. Grallert and A. Dehghan and M. Kuningas and {de Vries}, P.S. and {de Bruijn}, R.F.A.G. and S.M. Willems and K. Heikkil{\"a} and K. Silventoinen and K.H. Pietilainen and V. Legry and V. Giedraitis and L. Goumidi and A.C. Syv{\"a}nen and K. Strauch and W. Koenig and P. Lichtner and C. Herder and A. Palotie and C. Menni and A.G. Uitterlinden and K. Kuulasmaa and A.S. Havulinna and L.A. Moreno and M. Gonzalez-Gross and A. Evans and D.A. Tregouet and J.W. Yarnell and J. Virtamo and J. Ferri{\`e}res and G. Veronesi and M. Perola and D. Arveiler and P. Brambilla and L. Lind and J. Kaprio and A. Hofman and B.H. Stricker and {van Duijn}, C.M. and {Arfan Ikram}, M. and O.H. Franco and D. Cottel and J. Dallongeville and A.S. Hall and A. Jula and M.D. Tobin and B.W.J.H. Penninx and A. Peters and C. Gieger and N.J. Samani and G.W. Montgomery and J.B. Whitfield and N.G. Martin and L. Groop and T.D. Spector and P.K. Magnusson and P. Amouyel and D.I. Boomsma and P.M. Nilsson and M.R. J{\"a}rvelin and V. Lyssenko and A. Metspalu and D.P. Strachan and V. Salomaa and S. Ripatti and N.L. Pedersen and I. Prokopenko and M.I. McCarthy and E. Ingelsson",

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language = "English",

volume = "64",

pages = "1841--1852",

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Fall, T, Hägg, S, Ploner, A, Mägi, R, Fischer, K, Draisma, HHM, Sarin, A-P, Benyamin, B, Ladenvall, C, Akerlund, M, Kals, M, Esko, T, Nelson, CP, Kaakinen, M, Huikari, V, Mangino, M, Meirhaeghe, A, Kristiansson, K, Nuotio, ML, Kobl, M, Grallert, H, Dehghan, A, Kuningas, M, de Vries, PS, de Bruijn, RFAG, Willems, SM, Heikkilä, K, Silventoinen, K, Pietilainen, KH, Legry, V, Giedraitis, V, Goumidi, L, Syvänen, AC, Strauch, K, Koenig, W, Lichtner, P, Herder, C, Palotie, A, Menni, C, Uitterlinden, AG, Kuulasmaa, K, Havulinna, AS, Moreno, LA, Gonzalez-Gross, M, Evans, A, Tregouet, DA, Yarnell, JW, Virtamo, J, Ferrières, J, Veronesi, G, Perola, M, Arveiler, D, Brambilla, P, Lind, L, Kaprio, J, Hofman, A, Stricker, BH, van Duijn, CM, Arfan Ikram, M, Franco, OH, Cottel, D, Dallongeville, J, Hall, AS, Jula, A, Tobin, MD, Penninx, BWJH, Peters, A, Gieger, C, Samani, NJ, Montgomery, GW, Whitfield, JB, Martin, NG, Groop, L, Spector, TD, Magnusson, PK, Amouyel, P, Boomsma, DI, Nilsson, PM, Järvelin, MR, Lyssenko, V, Metspalu, A, Strachan, DP, Salomaa, V, Ripatti, S, Pedersen, NL, Prokopenko, I, McCarthy, MI & Ingelsson, E 2015, 'Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors', Diabetes, vol. 64, no. 5, pp. 1841-1852. https://doi.org/10.2337/db14-0988

TY - JOUR

T1 - Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors

AU - Fall, T.

AU - Hägg, S.

AU - Ploner, A.

AU - Mägi, R.

AU - Fischer, K.

AU - Draisma, H.H.M.

AU - Sarin, A.-P.

AU - Benyamin, B.

AU - Ladenvall, C.

AU - Akerlund, M.

AU - Kals, M.

AU - Esko, T.

AU - Nelson, C.P.

AU - Kaakinen, M.

AU - Huikari, V.

AU - Mangino, M.

AU - Meirhaeghe, A.

AU - Kristiansson, K.

AU - Nuotio, M.L.

AU - Kobl, M.

AU - Grallert, H.

AU - Dehghan, A.

AU - Kuningas, M.

AU - de Vries, P.S.

AU - de Bruijn, R.F.A.G.

AU - Willems, S.M.

AU - Heikkilä, K.

AU - Silventoinen, K.

AU - Pietilainen, K.H.

AU - Legry, V.

AU - Giedraitis, V.

AU - Goumidi, L.

AU - Syvänen, A.C.

AU - Strauch, K.

AU - Koenig, W.

AU - Lichtner, P.

AU - Herder, C.

AU - Palotie, A.

AU - Menni, C.

AU - Uitterlinden, A.G.

AU - Kuulasmaa, K.

AU - Havulinna, A.S.

AU - Moreno, L.A.

AU - Gonzalez-Gross, M.

AU - Evans, A.

AU - Tregouet, D.A.

AU - Yarnell, J.W.

AU - Virtamo, J.

AU - Ferrières, J.

AU - Veronesi, G.

AU - Perola, M.

AU - Arveiler, D.

AU - Brambilla, P.

AU - Lind, L.

AU - Kaprio, J.

AU - Hofman, A.

AU - Stricker, B.H.

AU - van Duijn, C.M.

AU - Arfan Ikram, M.

AU - Franco, O.H.

AU - Cottel, D.

AU - Dallongeville, J.

AU - Hall, A.S.

AU - Jula, A.

AU - Tobin, M.D.

AU - Penninx, B.W.J.H.

AU - Peters, A.

AU - Gieger, C.

AU - Samani, N.J.

AU - Montgomery, G.W.

AU - Whitfield, J.B.

AU - Martin, N.G.

AU - Groop, L.

AU - Spector, T.D.

AU - Magnusson, P.K.

AU - Amouyel, P.

AU - Boomsma, D.I.

AU - Nilsson, P.M.

AU - Järvelin, M.R.

AU - Lyssenko, V.

AU - Metspalu, A.

AU - Strachan, D.P.

AU - Salomaa, V.

AU - Ripatti, S.

AU - Pedersen, N.L.

AU - Prokopenko, I.

AU - McCarthy, M.I.

AU - Ingelsson, E.

PY - 2015

Y1 - 2015

N2 - Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 10

AB - Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 10

U2 - https://doi.org/10.2337/db14-0988

DO - https://doi.org/10.2337/db14-0988

M3 - Article

C2 - 25712996

SN - 0012-1797

VL - 64

SP - 1841

EP - 1852

JO - Diabetes

JF - Diabetes

IS - 5

ER -