Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

Peter L. M. Jansen; Jochem van Werven; Edo Aarts; Frits Berends; Ignace Janssen; Jaap Stoker; Frank G. Schaap

doi:https://doi.org/10.1159/000324128

Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

Peter L. M. Jansen, Jochem van Werven, Edo Aarts, Frits Berends, Ignace Janssen, Jaap Stoker, Frank G. Schaap

Research output: Contribution to journal › Article › Academic › peer-review

111 Citations (Scopus)

Abstract

Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated

Original language	English
Pages (from-to)	48-51
Journal	Digestive diseases (Basel, Switzerland)
Volume	29
Issue number	1
DOIs	https://doi.org/10.1159/000324128
Publication status	Published - 2011

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https://doi.org/10.1159/000324128

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abstract = "Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated",

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AU - Jansen, Peter L. M.

AU - van Werven, Jochem

AU - Aarts, Edo

AU - Berends, Frits

AU - Janssen, Ignace

AU - Stoker, Jaap

AU - Schaap, Frank G.

PY - 2011

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AB - Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated

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