TY - JOUR
T1 - Amide proton transfer-weighted imaging of pediatric brainstem glioma and its predicted value for H3 K27 alteration
AU - Cheng, Dan
AU - Zhuo, Zhizheng
AU - Zhang, Peng
AU - Qu, Liying
AU - Duan, Yunyun
AU - Xu, Xiaolu
AU - Xie, Cong
AU - Liu, Xing
AU - Haller, Sven
AU - Barkhof, Frederik
AU - Zhang, Liwei
AU - Liu, Yaou
N1 - Funding Information: Funding was provided by the National Science Foundation of China (Nos. 81870958 and 81571631), the Beijing Municipal Natural Science Foundation for Distinguished Young Scholars (No. JQ20035) and the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority (No. XTYB201831). FB is supported by the NIHR biomedical research center at UCLH. Publisher Copyright: © The Foundation Acta Radiologica 2023.
PY - 2023/11
Y1 - 2023/11
N2 - Background: Non-invasive determination of H3 K27 alteration of pediatric brainstem glioma (pedBSG) remains a clinical challenge. Purpose: To predict H3 K27-altered pedBSG using amide proton transfer-weighted (APTw) imaging. Material and Methods: This retrospective study included patients with pedBSG who underwent APTw imaging and had the H3 K27 alteration status determined by immunohistochemical staining. The presence or absence of foci of markedly increased APTw signal in the lesion was visually assessed. Quantitative APTw histogram parameters within the entire solid portion of tumors were extracted and compared between H3 K27-altered and wild-type groups using Student's t-test. The ability of APTw for differential diagnosis was evaluated using logistic regression. Results: Sixty pedBSG patients included 48 patients with H3 K27-altered tumor (aged 2–48 years) and 12 patients with wild-type tumor (aged 3–53 years). Visual assessment showed that the foci of markedly increased APTw signal intensity were more common in the H3 K27-altered group than in wild-type group (60% vs. 16%, P = 0.007). Histogram parameters of APTw signal intensity in the H3 K27-altered group were significantly higher than those in the wild-type group (median, 2.74% vs. 2.22%, P = 0.02). The maximum (area under the receiver operating characteristic curve [AUC] = 0.72, P = 0.01) showed the highest diagnostic performance among histogram analysis. A combination of age, median and maximum APTw signal intensity could predict H3 K27 alteration with a sensitivity of 81%, specificity of 75% and AUC of 0.80. Conclusion: APTw imaging may serve as an imaging biomarker for H3 K27 alteration of pedBSGs.
AB - Background: Non-invasive determination of H3 K27 alteration of pediatric brainstem glioma (pedBSG) remains a clinical challenge. Purpose: To predict H3 K27-altered pedBSG using amide proton transfer-weighted (APTw) imaging. Material and Methods: This retrospective study included patients with pedBSG who underwent APTw imaging and had the H3 K27 alteration status determined by immunohistochemical staining. The presence or absence of foci of markedly increased APTw signal in the lesion was visually assessed. Quantitative APTw histogram parameters within the entire solid portion of tumors were extracted and compared between H3 K27-altered and wild-type groups using Student's t-test. The ability of APTw for differential diagnosis was evaluated using logistic regression. Results: Sixty pedBSG patients included 48 patients with H3 K27-altered tumor (aged 2–48 years) and 12 patients with wild-type tumor (aged 3–53 years). Visual assessment showed that the foci of markedly increased APTw signal intensity were more common in the H3 K27-altered group than in wild-type group (60% vs. 16%, P = 0.007). Histogram parameters of APTw signal intensity in the H3 K27-altered group were significantly higher than those in the wild-type group (median, 2.74% vs. 2.22%, P = 0.02). The maximum (area under the receiver operating characteristic curve [AUC] = 0.72, P = 0.01) showed the highest diagnostic performance among histogram analysis. A combination of age, median and maximum APTw signal intensity could predict H3 K27 alteration with a sensitivity of 81%, specificity of 75% and AUC of 0.80. Conclusion: APTw imaging may serve as an imaging biomarker for H3 K27 alteration of pedBSGs.
KW - H3 K27 alteration
KW - Pediatric brainstem glioma
KW - amide proton transfer-weighted imaging
KW - histogram analysis
UR - http://www.scopus.com/inward/record.url?scp=85171432813&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/02841851231197503
DO - https://doi.org/10.1177/02841851231197503
M3 - Article
C2 - 37722801
SN - 0284-1851
VL - 64
SP - 2922
EP - 2930
JO - Acta radiologica (Stockholm, Sweden
JF - Acta radiologica (Stockholm, Sweden
IS - 11
ER -