Antiretroviral therapy and tuberculosis: does the regimen matter?: Does the regimen matter?

Frank van Leth; Ferdinand W. N. M. Wit; Sabine M. Hermans

doi:https://doi.org/10.1586/14787210.2014.859984

Antiretroviral therapy and tuberculosis: does the regimen matter? Does the regimen matter?

Frank van Leth, Ferdinand W. N. M. Wit, Sabine M. Hermans

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

Infection with HIV is one of the strongest drivers of the incidence of tuberculosis. The use of potent combination antiretroviral therapy (cART) decreases the incidence of tuberculosis in HIV-infected patients. Data on whether this effect differs by type of initial antiretroviral drug or regimen are scarce. Studies are often not designed to address the potential effect of cART on tuberculosis incidence, and/or the diagnosis of tuberculosis is poorly validated. The paucity of data precludes recommendation on the initial cART regimen with respect to the incidence tuberculosis. Other well-described intervention like preventive therapy, and early start with cART are likely to have more effect on the prevention on tuberculosis in HIV-infected patients

Original language	English
Pages (from-to)	5-7
Journal	Expert Review of Anti-Infective Therapy
Volume	12
Issue number	1
DOIs	https://doi.org/10.1586/14787210.2014.859984
Publication status	Published - Jan 2014

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https://doi.org/10.1586/14787210.2014.859984

Cite this

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title = "Antiretroviral therapy and tuberculosis: does the regimen matter?: Does the regimen matter?",

abstract = "Infection with HIV is one of the strongest drivers of the incidence of tuberculosis. The use of potent combination antiretroviral therapy (cART) decreases the incidence of tuberculosis in HIV-infected patients. Data on whether this effect differs by type of initial antiretroviral drug or regimen are scarce. Studies are often not designed to address the potential effect of cART on tuberculosis incidence, and/or the diagnosis of tuberculosis is poorly validated. The paucity of data precludes recommendation on the initial cART regimen with respect to the incidence tuberculosis. Other well-described intervention like preventive therapy, and early start with cART are likely to have more effect on the prevention on tuberculosis in HIV-infected patients",

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AU - Hermans, Sabine M.

PY - 2014/1

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N2 - Infection with HIV is one of the strongest drivers of the incidence of tuberculosis. The use of potent combination antiretroviral therapy (cART) decreases the incidence of tuberculosis in HIV-infected patients. Data on whether this effect differs by type of initial antiretroviral drug or regimen are scarce. Studies are often not designed to address the potential effect of cART on tuberculosis incidence, and/or the diagnosis of tuberculosis is poorly validated. The paucity of data precludes recommendation on the initial cART regimen with respect to the incidence tuberculosis. Other well-described intervention like preventive therapy, and early start with cART are likely to have more effect on the prevention on tuberculosis in HIV-infected patients

AB - Infection with HIV is one of the strongest drivers of the incidence of tuberculosis. The use of potent combination antiretroviral therapy (cART) decreases the incidence of tuberculosis in HIV-infected patients. Data on whether this effect differs by type of initial antiretroviral drug or regimen are scarce. Studies are often not designed to address the potential effect of cART on tuberculosis incidence, and/or the diagnosis of tuberculosis is poorly validated. The paucity of data precludes recommendation on the initial cART regimen with respect to the incidence tuberculosis. Other well-described intervention like preventive therapy, and early start with cART are likely to have more effect on the prevention on tuberculosis in HIV-infected patients

U2 - https://doi.org/10.1586/14787210.2014.859984

DO - https://doi.org/10.1586/14787210.2014.859984

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