Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance

P. A. Kager; M. J. Schultz; E. E. Zijlstra; B. van den Berg; C. J. van Boxtel

doi:https://doi.org/10.1016/0035-9203(94)90475-8

Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance

P. A. Kager, M. J. Schultz, E. E. Zijlstra, B. van den Berg, C. J. van Boxtel

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Abstract

The recently developed artemisinin derivative arteether was administered by intramuscular injection to healthy male subjects in a single dose (n = 23) and a multiple dose study (n = 27). The drug was well tolerated. Clinical, neurological, electrocardiographic and biochemical monitoring did not reveal significant toxicity. Apart from some increase in eosinophil numbers, no haematological abnormality was seen. Preliminary pharmacokinetic data showed a long elimination half life of 25-72 h and marked accumulation in the multiple dose study

Original language	English
Pages (from-to)	S53-S54
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	88
Issue number	Suppl. 1
DOIs	https://doi.org/10.1016/0035-9203(94)90475-8
Publication status	Published - 1994

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https://doi.org/10.1016/0035-9203(94)90475-8

Cite this

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title = "Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance",

abstract = "The recently developed artemisinin derivative arteether was administered by intramuscular injection to healthy male subjects in a single dose (n = 23) and a multiple dose study (n = 27). The drug was well tolerated. Clinical, neurological, electrocardiographic and biochemical monitoring did not reveal significant toxicity. Apart from some increase in eosinophil numbers, no haematological abnormality was seen. Preliminary pharmacokinetic data showed a long elimination half life of 25-72 h and marked accumulation in the multiple dose study",

author = "Kager, {P. A.} and Schultz, {M. J.} and Zijlstra, {E. E.} and {van den Berg}, B. and {van Boxtel}, {C. J.}",

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AU - van den Berg, B.

AU - van Boxtel, C. J.

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DO - https://doi.org/10.1016/0035-9203(94)90475-8

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