TY - JOUR
T1 - Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia
AU - Campian, M.E.
AU - Verberne, H.J.
AU - Hardziyenka, M.
AU - de Groot, E.A.A.
AU - van Moerkerken, A.F.
AU - van Eck-Smit, B.L.F.
AU - Tan, H.L.
PY - 2010
Y1 - 2010
N2 - Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a myocardial disease that predominantly affects the right ventricle (RV). Its hallmark feature is fibro-fatty replacement of RV myocardium. However, patchy inflammatory infiltrates in the RV are also consistently reported using autopsy and myocardial biopsy. Although the role of inflammation in ARVC/D is unresolved, the ability to assess inflammation non-invasively may aid in the diagnostic process. We aimed to establish whether cardiac inflammation can be assessed non-invasively in ARVC/D patients. In eight ARVC/D patients and nine controls (haematology/oncology patients), the level of inflammatory activation was assessed by measuring plasma levels of inflammatory cytokines. Regional myocardial inflammation was assessed with Ga-67 scintigraphy. ARVC/D patients had higher plasma levels than controls of the pro-inflammatory cytokines interleukin (IL)-1 beta (1.22 +/- 0.07 vs 0.08 +/- 0.01 pg/ml, p < 0.0001), IL-6 (3.16 +/- 0.44 vs 0.38 +/- 0.04 pg/ml, p < 0.0001) and tumour necrosis factor (TNF)-alpha (9.16 +/- 0.90 vs 0.40 +/- 0.06 pg/ml, p < 0.0001), while levels of the anti-inflammatory cytokine IL-10 were not significantly different (1.36 +/- 0.15 vs 1.20 +/- 0.30 pg/ml, p = 0.74). Ga-67 uptake in the RV was higher in ARVC/D patients than in controls. In ARVC/D patients, Ga-67 uptake in the RV wall was higher than in the interventricular septum or left ventricular wall. Inflammation in the RV wall of ARVC/D patients can be detected non-invasively with the combined analysis of plasma levels of inflammatory cytokines and cardiac Ga-67 scintigraphy
AB - Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a myocardial disease that predominantly affects the right ventricle (RV). Its hallmark feature is fibro-fatty replacement of RV myocardium. However, patchy inflammatory infiltrates in the RV are also consistently reported using autopsy and myocardial biopsy. Although the role of inflammation in ARVC/D is unresolved, the ability to assess inflammation non-invasively may aid in the diagnostic process. We aimed to establish whether cardiac inflammation can be assessed non-invasively in ARVC/D patients. In eight ARVC/D patients and nine controls (haematology/oncology patients), the level of inflammatory activation was assessed by measuring plasma levels of inflammatory cytokines. Regional myocardial inflammation was assessed with Ga-67 scintigraphy. ARVC/D patients had higher plasma levels than controls of the pro-inflammatory cytokines interleukin (IL)-1 beta (1.22 +/- 0.07 vs 0.08 +/- 0.01 pg/ml, p < 0.0001), IL-6 (3.16 +/- 0.44 vs 0.38 +/- 0.04 pg/ml, p < 0.0001) and tumour necrosis factor (TNF)-alpha (9.16 +/- 0.90 vs 0.40 +/- 0.06 pg/ml, p < 0.0001), while levels of the anti-inflammatory cytokine IL-10 were not significantly different (1.36 +/- 0.15 vs 1.20 +/- 0.30 pg/ml, p = 0.74). Ga-67 uptake in the RV was higher in ARVC/D patients than in controls. In ARVC/D patients, Ga-67 uptake in the RV wall was higher than in the interventricular septum or left ventricular wall. Inflammation in the RV wall of ARVC/D patients can be detected non-invasively with the combined analysis of plasma levels of inflammatory cytokines and cardiac Ga-67 scintigraphy
U2 - https://doi.org/10.1007/s00259-010-1525-y
DO - https://doi.org/10.1007/s00259-010-1525-y
M3 - Article
C2 - 20603720
SN - 1619-7070
VL - 37
SP - 2079
EP - 2085
JO - European journal of nuclear medicine and molecular imaging
JF - European journal of nuclear medicine and molecular imaging
IS - 11
ER -