Association between arterial stiffness and the deformability of red blood cells (RBCs)

S. S. Lee; N. J. Kim; K. Sun; J. G. Dobbe; M. R. Hardeman; J. F. Antaki; K. H. Ahn; S. J. Lee

Association between arterial stiffness and the deformability of red blood cells (RBCs)

S. S. Lee, N. J. Kim, K. Sun, J. G. Dobbe, M. R. Hardeman, J. F. Antaki, K. H. Ahn, S. J. Lee

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

The relationship between the flexibility of atherosclerotic vessels and RBC deformability has been investigated. A significant difference of RBC deformability was found among the arterial stiffness groups classified by oscillometric measurement of blood pressure. The deformability was determined by direct microscopic observation of RBCs subjected to shear stress of 0.3 to 40.0 Pa with a rotating rheoscope. The deformability of stiffen group - abnormal pulse wave pattern group or moderate cardiovascular risk group - was found to be much higher than that of normal groups in wide shear stress region (3.0, 10.0, 30.0, and 40.0 Pa). We postulate that the body adapts high shear stress in vivo by making RBCs more distensible, and therefore less likely to rupture under strain or microcirculatory alterations

Original language	English
Pages (from-to)	475-481
Journal	Clinical Hemorheology and Microcirculation
Volume	34
Issue number	4
Publication status	Published - 2006

Cite this

@article{e20e62a033ca460694666a158d49e339,

title = "Association between arterial stiffness and the deformability of red blood cells (RBCs)",

abstract = "The relationship between the flexibility of atherosclerotic vessels and RBC deformability has been investigated. A significant difference of RBC deformability was found among the arterial stiffness groups classified by oscillometric measurement of blood pressure. The deformability was determined by direct microscopic observation of RBCs subjected to shear stress of 0.3 to 40.0 Pa with a rotating rheoscope. The deformability of stiffen group - abnormal pulse wave pattern group or moderate cardiovascular risk group - was found to be much higher than that of normal groups in wide shear stress region (3.0, 10.0, 30.0, and 40.0 Pa). We postulate that the body adapts high shear stress in vivo by making RBCs more distensible, and therefore less likely to rupture under strain or microcirculatory alterations",

author = "Lee, {S. S.} and Kim, {N. J.} and K. Sun and Dobbe, {J. G.} and Hardeman, {M. R.} and Antaki, {J. F.} and Ahn, {K. H.} and Lee, {S. J.}",

year = "2006",

language = "English",

volume = "34",

pages = "475--481",

journal = "Clinical Hemorheology and Microcirculation",

issn = "1386-0291",

publisher = "IOS Press",

number = "4",

}

TY - JOUR

T1 - Association between arterial stiffness and the deformability of red blood cells (RBCs)

AU - Lee, S. S.

AU - Kim, N. J.

AU - Sun, K.

AU - Dobbe, J. G.

AU - Hardeman, M. R.

AU - Antaki, J. F.

AU - Ahn, K. H.

AU - Lee, S. J.

PY - 2006

Y1 - 2006

N2 - The relationship between the flexibility of atherosclerotic vessels and RBC deformability has been investigated. A significant difference of RBC deformability was found among the arterial stiffness groups classified by oscillometric measurement of blood pressure. The deformability was determined by direct microscopic observation of RBCs subjected to shear stress of 0.3 to 40.0 Pa with a rotating rheoscope. The deformability of stiffen group - abnormal pulse wave pattern group or moderate cardiovascular risk group - was found to be much higher than that of normal groups in wide shear stress region (3.0, 10.0, 30.0, and 40.0 Pa). We postulate that the body adapts high shear stress in vivo by making RBCs more distensible, and therefore less likely to rupture under strain or microcirculatory alterations

AB - The relationship between the flexibility of atherosclerotic vessels and RBC deformability has been investigated. A significant difference of RBC deformability was found among the arterial stiffness groups classified by oscillometric measurement of blood pressure. The deformability was determined by direct microscopic observation of RBCs subjected to shear stress of 0.3 to 40.0 Pa with a rotating rheoscope. The deformability of stiffen group - abnormal pulse wave pattern group or moderate cardiovascular risk group - was found to be much higher than that of normal groups in wide shear stress region (3.0, 10.0, 30.0, and 40.0 Pa). We postulate that the body adapts high shear stress in vivo by making RBCs more distensible, and therefore less likely to rupture under strain or microcirculatory alterations

M3 - Article

C2 - 16687787

SN - 1386-0291

VL - 34

SP - 475

EP - 481

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

IS - 4

ER -