Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Sergey Nejentsev; Cristian Guja; Rose McCormack; Jason Cooper; Joanna M M Howson; Sarah Nutland; Helen Rance; Neil Walker; Dag Undlien; Kjersti S Ronningen; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Constantin Ionescu-Tirgoviste; Edwin A M Gale; Polly J Bingley; Kathleen M Gillespie; David A Savage; Dennis J Carson; Chris C Patterson; A Peter Maxwell; John A Todd

doi:https://doi.org/10.1016/S0140-6736(03)14847-7

Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Sergey Nejentsev, Cristian Guja, Rose McCormack, Jason Cooper, Joanna M M Howson, Sarah Nutland, Helen Rance, Neil Walker, Dag Undlien, Kjersti S Ronningen, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Constantin Ionescu-Tirgoviste, Edwin A M Gale, Polly J Bingley, Kathleen M Gillespie, David A Savage, Dennis J Carson, Chris C Patterson, A Peter MaxwellJohn A Todd

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

Original language	English
Pages (from-to)	1723-4
Number of pages	2
Journal	Lancet
Volume	362
Issue number	9397
DOIs	https://doi.org/10.1016/S0140-6736(03)14847-7
Publication status	Published - 22 Nov 2003
Externally published	Yes

Keywords

Diabetes Mellitus, Type 1/genetics
Humans
Intercellular Adhesion Molecule-1/genetics
Pedigree
Polymorphism, Single Nucleotide

Access to Document

https://doi.org/10.1016/S0140-6736(03)14847-7

Cite this

Nejentsev, S., Guja, C., McCormack, R., Cooper, J., Howson, J. M. M., Nutland, S., Rance, H., Walker, N., Undlien, D., Ronningen, K. S., Tuomilehto-Wolf, E., Tuomilehto, J., Ionescu-Tirgoviste, C., Gale, E. A. M., Bingley, P. J., Gillespie, K. M., Savage, D. A., Carson, D. J., Patterson, C. C., ... Todd, J. A. (2003). Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet, 362(9397), 1723-4. https://doi.org/10.1016/S0140-6736(03)14847-7

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title = "Association of intercellular adhesion molecule-1 gene with type 1 diabetes",

abstract = "Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.",

keywords = "Diabetes Mellitus, Type 1/genetics, Humans, Intercellular Adhesion Molecule-1/genetics, Pedigree, Polymorphism, Single Nucleotide",

author = "Sergey Nejentsev and Cristian Guja and Rose McCormack and Jason Cooper and Howson, {Joanna M M} and Sarah Nutland and Helen Rance and Neil Walker and Dag Undlien and Ronningen, {Kjersti S} and Eva Tuomilehto-Wolf and Jaakko Tuomilehto and Constantin Ionescu-Tirgoviste and Gale, {Edwin A M} and Bingley, {Polly J} and Gillespie, {Kathleen M} and Savage, {David A} and Carson, {Dennis J} and Patterson, {Chris C} and Maxwell, {A Peter} and Todd, {John A}",

year = "2003",

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doi = "https://doi.org/10.1016/S0140-6736(03)14847-7",

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Nejentsev, S, Guja, C, McCormack, R, Cooper, J, Howson, JMM, Nutland, S, Rance, H, Walker, N, Undlien, D, Ronningen, KS, Tuomilehto-Wolf, E, Tuomilehto, J, Ionescu-Tirgoviste, C, Gale, EAM, Bingley, PJ, Gillespie, KM, Savage, DA, Carson, DJ, Patterson, CC, Maxwell, AP & Todd, JA 2003, 'Association of intercellular adhesion molecule-1 gene with type 1 diabetes', Lancet, vol. 362, no. 9397, pp. 1723-4. https://doi.org/10.1016/S0140-6736(03)14847-7

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T1 - Association of intercellular adhesion molecule-1 gene with type 1 diabetes

AU - Nejentsev, Sergey

AU - Guja, Cristian

AU - McCormack, Rose

AU - Cooper, Jason

AU - Howson, Joanna M M

AU - Nutland, Sarah

AU - Rance, Helen

AU - Walker, Neil

AU - Undlien, Dag

AU - Ronningen, Kjersti S

AU - Tuomilehto-Wolf, Eva

AU - Tuomilehto, Jaakko

AU - Ionescu-Tirgoviste, Constantin

AU - Gale, Edwin A M

AU - Bingley, Polly J

AU - Gillespie, Kathleen M

AU - Savage, David A

AU - Carson, Dennis J

AU - Patterson, Chris C

AU - Maxwell, A Peter

AU - Todd, John A

PY - 2003/11/22

Y1 - 2003/11/22

N2 - Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

AB - Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

KW - Diabetes Mellitus, Type 1/genetics

KW - Humans

KW - Intercellular Adhesion Molecule-1/genetics

KW - Pedigree

KW - Polymorphism, Single Nucleotide

U2 - https://doi.org/10.1016/S0140-6736(03)14847-7

DO - https://doi.org/10.1016/S0140-6736(03)14847-7

M3 - Article

C2 - 14643123

SN - 0140-6736

VL - 362

SP - 1723

EP - 1724

JO - Lancet

JF - Lancet

IS - 9397

ER -