Abstract
Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems of mutually interacting symptoms. This perspective implies that a more densely connected network of symptoms is indicative of a poorer prognosis, but, to date, no previous study has examined whether network structure is indeed associated with the longitudinal course of MDD.
Original language | English |
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Pages (from-to) | 1219-1226 |
Number of pages | 8 |
Journal | JAMA Psychiatry |
Volume | 72 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2015 |
Keywords
- Adult
- Depressive Disorder, Major/diagnosis
- Disease Progression
- Female
- Humans
- Male
- Models, Psychological
- Prospective Studies
- Remission Induction
- Symptom Assessment