Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Mark E. Lobatto; Claudia Calcagno; Antoine Millon; Max L. Senders; Francois Fay; Philip M. Robson; Sarayu Ramachandran; Tina Binderup; Maarten P. M. Paridaans; Steven Sensarn; Stephan Rogalla; Ronald E. Gordon; Luis Cardoso; Gert Storm; Josbert M. Metselaar; Christopher H. Contag; Erik S. G. Stroes; Zahi A. Fayad; Willem J. M. Mulder

doi:https://doi.org/10.1021/nn506750r

Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Mark E. Lobatto, Claudia Calcagno, Antoine Millon, Max L. Senders, Francois Fay, Philip M. Robson, Sarayu Ramachandran, Tina Binderup, Maarten P. M. Paridaans, Steven Sensarn, Stephan Rogalla, Ronald E. Gordon, Luis Cardoso, Gert Storm, Josbert M. Metselaar, Christopher H. Contag, Erik S. G. Stroes, Zahi A. Fayad, Willem J. M. Mulder

Research output: Contribution to journal › Article › Academic › peer-review

107 Citations (Scopus)

Abstract

Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis

Original language	English
Pages (from-to)	1837-1847
Journal	ACS nano
Volume	9
Issue number	2
DOIs	https://doi.org/10.1021/nn506750r
Publication status	Published - 2015

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https://doi.org/10.1021/nn506750r

Cite this

Lobatto, M. E., Calcagno, C., Millon, A., Senders, M. L., Fay, F., Robson, P. M., Ramachandran, S., Binderup, T., Paridaans, M. P. M., Sensarn, S., Rogalla, S., Gordon, R. E., Cardoso, L., Storm, G., Metselaar, J. M., Contag, C. H., Stroes, E. S. G., Fayad, Z. A., & Mulder, W. J. M. (2015). Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS nano, 9(2), 1837-1847. https://doi.org/10.1021/nn506750r

@article{644cc937575a46a0b4b2759a248268e1,

title = "Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging",

abstract = "Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis",

author = "Lobatto, {Mark E.} and Claudia Calcagno and Antoine Millon and Senders, {Max L.} and Francois Fay and Robson, {Philip M.} and Sarayu Ramachandran and Tina Binderup and Paridaans, {Maarten P. M.} and Steven Sensarn and Stephan Rogalla and Gordon, {Ronald E.} and Luis Cardoso and Gert Storm and Metselaar, {Josbert M.} and Contag, {Christopher H.} and Stroes, {Erik S. G.} and Fayad, {Zahi A.} and Mulder, {Willem J. M.}",

year = "2015",

doi = "https://doi.org/10.1021/nn506750r",

language = "English",

volume = "9",

pages = "1837--1847",

journal = "ACS nano",

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publisher = "American Chemical Society",

number = "2",

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Lobatto, ME, Calcagno, C, Millon, A, Senders, ML, Fay, F, Robson, PM, Ramachandran, S, Binderup, T, Paridaans, MPM, Sensarn, S, Rogalla, S, Gordon, RE, Cardoso, L, Storm, G, Metselaar, JM, Contag, CH, Stroes, ESG, Fayad, ZA & Mulder, WJM 2015, 'Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging', ACS nano, vol. 9, no. 2, pp. 1837-1847. https://doi.org/10.1021/nn506750r

TY - JOUR

T1 - Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

AU - Lobatto, Mark E.

AU - Calcagno, Claudia

AU - Millon, Antoine

AU - Senders, Max L.

AU - Fay, Francois

AU - Robson, Philip M.

AU - Ramachandran, Sarayu

AU - Binderup, Tina

AU - Paridaans, Maarten P. M.

AU - Sensarn, Steven

AU - Rogalla, Stephan

AU - Gordon, Ronald E.

AU - Cardoso, Luis

AU - Storm, Gert

AU - Metselaar, Josbert M.

AU - Contag, Christopher H.

AU - Stroes, Erik S. G.

AU - Fayad, Zahi A.

AU - Mulder, Willem J. M.

PY - 2015

Y1 - 2015

N2 - Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis

AB - Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis

U2 - https://doi.org/10.1021/nn506750r

DO - https://doi.org/10.1021/nn506750r

M3 - Article

C2 - 25619964

SN - 1936-0851

VL - 9

SP - 1837

EP - 1847

JO - ACS nano

JF - ACS nano

IS - 2

ER -