BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain

A.H. Sillars-Hardebol, B. Carvalho, J.A.M. Belien, M. de Wit, P.M. Delis-van Diemen, M. Tijssen, M.A. van de Wiel, F. Ponten, R.J.A. Fijneman, G.A. Meijer

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Abstract

Colorectal cancer (CRC) is the second leading cause of cancer death in the western world. The majority of CRCs, which develop from adenoma precursor lesions, show gain of chromosome arm 20q, where BCL2L1 is located. BCL2L1 is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-x
Original languageEnglish
Pages (from-to)442-450
JournalJournal of pathology
Volume226
Issue number3
Early online date18 Aug 2011
DOIs
Publication statusPublished - 2012

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