Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

Emre Almac; Rick Bezemer; Asli Kandil; Ugur Aksu; Dan M. J. Milstein; Jan Bakker; Cihan Demirci-Tansel; Can Ince

doi:https://doi.org/10.1186/2197-425X-2-3

Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

Emre Almac, Rick Bezemer, Asli Kandil, Ugur Aksu, Dan M. J. Milstein, Jan Bakker, Cihan Demirci-Tansel, Can Ince

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia). Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function. The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption. Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury

Original language	English
Pages (from-to)	6
Journal	Intensive Care Medicine Experimental
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/2197-425X-2-3
Publication status	Published - 2014

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https://doi.org/10.1186/2197-425X-2-3

Cite this

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title = "Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats",

abstract = "The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia). Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function. The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption. Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury",

author = "Emre Almac and Rick Bezemer and Asli Kandil and Ugur Aksu and Milstein, {Dan M. J.} and Jan Bakker and Cihan Demirci-Tansel and Can Ince",

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T1 - Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats

AU - Almac, Emre

AU - Bezemer, Rick

AU - Kandil, Asli

AU - Aksu, Ugur

AU - Milstein, Dan M. J.

AU - Bakker, Jan

AU - Demirci-Tansel, Cihan

AU - Ince, Can

PY - 2014

Y1 - 2014

N2 - The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia). Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function. The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption. Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury

AB - The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ischemia) and its effects on renal oxygenation and renal function in the acute phase of reperfusion (up to 90 min post-ischemia). Ischemia was established in anesthetized and mechanically ventilated male Wistar rats by renal artery clamping. Renal microvascular and venous oxygenation were measured using phosphorimetry. Creatinine clearance rate, sodium reabsorption, and renal oxygen handling efficiency were considered markers for renal function. The main findings were that BMOV did not affect the systemic and renal hemodynamic and oxygenation variables and partially protected renal sodium reabsorption. Pretreatment with the organic vanadium compound BMOV did not protect the kidney from I/R injury

U2 - https://doi.org/10.1186/2197-425X-2-3

DO - https://doi.org/10.1186/2197-425X-2-3

M3 - Article

C2 - 26266905

SN - 2197-425X

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