TY - CHAP
T1 - Blood-Brain Barrier Disruption in Multiple Sclerosis
AU - Mizee, M.R.
AU - van Doorn, R.P.
AU - Prat, A.
AU - de Vries, H.E.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The blood-brain barrier is specialized to function as a barrier to protect the central nervous system by restricting entry of unwanted molecules and immune cells into the brain and inversely, to prevent central nervous system-born agents from reaching the systemic circulation. The blood-brain barrier endothelium, together with cells involved in its regulation forms the neurovascular unit. Blood-brain barrier dysfunction is an important hallmark of early multiple sclerosis pathophysiology, leading to a consequent loss of the imperative brain homeostasis and subsequent neuronal dysfunction and damage. The neuroinfl ammatory changes at the blood-brain barrier are numerous and include the loss of barrier function, altered communication with surrounding cells, and activation of both infl ammation promoting and dampening mechanisms. A better understanding of blood-brain barrier alterations in neuroinfl ammation might lead to new ways to promote blood-brain barrier function in neurological diseases like multiple sclerosis.
AB - The blood-brain barrier is specialized to function as a barrier to protect the central nervous system by restricting entry of unwanted molecules and immune cells into the brain and inversely, to prevent central nervous system-born agents from reaching the systemic circulation. The blood-brain barrier endothelium, together with cells involved in its regulation forms the neurovascular unit. Blood-brain barrier dysfunction is an important hallmark of early multiple sclerosis pathophysiology, leading to a consequent loss of the imperative brain homeostasis and subsequent neuronal dysfunction and damage. The neuroinfl ammatory changes at the blood-brain barrier are numerous and include the loss of barrier function, altered communication with surrounding cells, and activation of both infl ammation promoting and dampening mechanisms. A better understanding of blood-brain barrier alterations in neuroinfl ammation might lead to new ways to promote blood-brain barrier function in neurological diseases like multiple sclerosis.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137485788&origin=inward
U2 - https://doi.org/10.1201/b19299-4
DO - https://doi.org/10.1201/b19299-4
M3 - Chapter
SN - 9781498727082
VL - 2
T3 - The Blood-Brain Barrier in Health and Disease: Volume 2: Pathophysiology and Pathology
SP - 1
EP - 22
BT - The Blood-Brain Barrier in Health and Disease: Volume 2: Pathophysiology and Pathology
PB - CRC Press
CY - Boca Raton, London, New York
ER -