TY - JOUR
T1 - Brain areas and pathways in the regulation of glucose metabolism
AU - Diepenbroek, Charlene
AU - Serlie, Mireille J.
AU - Fliers, Eric
AU - Kalsbeek, Andries
AU - la Fleur, Susanne E.
PY - 2013
Y1 - 2013
N2 - Glucose is the most important source of fuel for the brain and its concentration must be kept within strict boundaries to ensure the organism's optimal fitness. To maintain glucose homeostasis, an optimal balance between glucose uptake and glucose output is required. Besides managing acute changes in plasma glucose concentrations, the brain controls a daily rhythm in glucose concentrations. The various nuclei within the hypothalamus that are involved in the control of both these processes are well known. However, novel studies indicate an additional role for brain areas that are originally appreciated in other processes than glucose metabolism. Therefore, besides the classic hypothalamic pathways, we will review cortico-limbic brain areas and their role in glucose metabolism
AB - Glucose is the most important source of fuel for the brain and its concentration must be kept within strict boundaries to ensure the organism's optimal fitness. To maintain glucose homeostasis, an optimal balance between glucose uptake and glucose output is required. Besides managing acute changes in plasma glucose concentrations, the brain controls a daily rhythm in glucose concentrations. The various nuclei within the hypothalamus that are involved in the control of both these processes are well known. However, novel studies indicate an additional role for brain areas that are originally appreciated in other processes than glucose metabolism. Therefore, besides the classic hypothalamic pathways, we will review cortico-limbic brain areas and their role in glucose metabolism
U2 - https://doi.org/10.1002/biof.1123
DO - https://doi.org/10.1002/biof.1123
M3 - Review article
C2 - 23913677
SN - 0951-6433
VL - 39
SP - 505
EP - 513
JO - BioFactors (Oxford, England)
JF - BioFactors (Oxford, England)
IS - 5
ER -