TY - JOUR
T1 - The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis
AU - Coerver, Eline M E
AU - Strijbis, Eva M M
AU - Petzold, Laura F
AU - Van Kempen, Zoé L E
AU - Jasperse, Bas
AU - Barkhof, Frederik
AU - Oudejans, Cees B M
AU - Uitdehaag, Bernard M J
AU - Teunissen, Charlotte E
AU - Killestein, Joep
N1 - Copyright © 2022 Coerver, Strijbis, Petzold, Van Kempen, Jasperse, Barkhof, Oudejans, Uitdehaag, Teunissen and Killestein.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Myxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AIM: To investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.METHODS: Baseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.RESULTS: Low MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91-13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.CONCLUSION: Baseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
AB - BACKGROUND: Myxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AIM: To investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.METHODS: Baseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.RESULTS: Low MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91-13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.CONCLUSION: Baseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
U2 - https://doi.org/10.3389/fneur.2022.907245
DO - https://doi.org/10.3389/fneur.2022.907245
M3 - Article
C2 - 36062003
SN - 1664-2295
VL - 13
SP - 907245
JO - Frontiers in Neurology
JF - Frontiers in Neurology
ER -