TY - JOUR
T1 - Cancer-on-chip models for metastasis
T2 - importance of the tumor microenvironment
AU - Jouybar, Mohammad
AU - de Winde, Charlotte M.
AU - Wolf, Katarina
AU - Friedl, Peter
AU - Mebius, Reina E.
AU - den Toonder, Jaap M. J.
N1 - Funding Information: We thank the Animation Study of TU Eindhoven for the graphic design of the figures. The work of M.J. is part of the Moore4Medical project funded by the ECSEL Joint Undertaking under grant number H2020-ECSEL-2019-IA-876190 . C.M.dW. is supported by the Cancer Center Amsterdam (grant no. CCA2019-9-57 and CCA2020-9-73 ) and the Dutch Cancer Foundation (KWF; Young Investigator Grant no. 2022-4 EXPL/14641 ). K.W. is supported by a grant from the Dutch Cancer Foundation KWF (grant number 11199 ). J.M.J.dT. and P.F. are supported by a grant from the Dutch Research Council NWO (grant number Science-XL 2019.022 , ‘The Active Matter Physics of Collective Metastasis’). Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.
AB - Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.
KW - Cancer-on-chip
KW - extracellular matrix
KW - immune system
KW - tumor microenvironment
KW - vasculature
UR - http://www.scopus.com/inward/record.url?scp=85175263255&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.tibtech.2023.10.001
DO - https://doi.org/10.1016/j.tibtech.2023.10.001
M3 - Review article
C2 - 37914546
SN - 0167-7799
JO - Trends in biotechnology
JF - Trends in biotechnology
ER -