TY - JOUR
T1 - Cardiac dysfunction in pneumovirus-induced lung injury in mice
AU - Bem, Reinout A.
AU - van den Berg, Elske
AU - Suidgeest, Ernst
AU - van der Weerd, Louise
AU - van Woensel, Job B. M.
AU - Grotenhuis, Heynric B.
PY - 2013
Y1 - 2013
N2 - To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice. Experimental animal study. Animal laboratory. C57Bl/6 mice. Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice. Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found. These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart
AB - To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice. Experimental animal study. Animal laboratory. C57Bl/6 mice. Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice. Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found. These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart
U2 - https://doi.org/10.1097/PCC.0b013e31828a7f9b
DO - https://doi.org/10.1097/PCC.0b013e31828a7f9b
M3 - Article
C2 - 23867445
SN - 1529-7535
VL - 14
SP - e243-e249
JO - Pediatric critical care medicine
JF - Pediatric critical care medicine
IS - 5
ER -