Cardiac sodium channels and inherited electrophysiologic disorders: A pharmacogenetic overview

Jeroen P.P. Smits; Marieke T. Blom; Arthur A.M. Wilde; Hanno L. Tan

doi:https://doi.org/10.1517/14656566.9.4.537

Cardiac sodium channels and inherited electrophysiologic disorders: A pharmacogenetic overview

Jeroen P.P. Smits, Marieke T. Blom, Arthur A.M. Wilde, Hanno L. Tan

Research output: Contribution to journal › Review article › Academic › peer-review

14 Citations (Scopus)

Abstract

Sodium (Na) channels are essential for cardiac electrical activity. Cardiac Na channel dysfunction, inherited or acquired, can induce life-threatening conduction and arrhythmia disorders. Inherited Na channel dysfunction may put affected patients at a greater risk for these complications when channel-modifying drugs are prescribed. This study addressed pharmacogenetic effects in three well-described Na channel-related diseases: long QT syndrome type 3, Brugada syndrome and inherited cardiac conduction disease. A review of the currently available literature on cardiac Na channel-modulating drugs was undertaken. An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms.

Original language	English
Pages (from-to)	537-549
Number of pages	13
Journal	Expert opinion on pharmacotherapy
Volume	9
Issue number	4
DOIs	https://doi.org/10.1517/14656566.9.4.537
Publication status	Published - Mar 2008

Keywords

Brugada syndrome
Cardiac arrhythmia syndromes
Conduction disease
Inherited
Long QT syndrome type 3
Pharmacogenomics
Sodium channel

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https://doi.org/10.1517/14656566.9.4.537

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title = "Cardiac sodium channels and inherited electrophysiologic disorders: A pharmacogenetic overview",

abstract = "Sodium (Na) channels are essential for cardiac electrical activity. Cardiac Na channel dysfunction, inherited or acquired, can induce life-threatening conduction and arrhythmia disorders. Inherited Na channel dysfunction may put affected patients at a greater risk for these complications when channel-modifying drugs are prescribed. This study addressed pharmacogenetic effects in three well-described Na channel-related diseases: long QT syndrome type 3, Brugada syndrome and inherited cardiac conduction disease. A review of the currently available literature on cardiac Na channel-modulating drugs was undertaken. An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms.",

keywords = "Brugada syndrome, Cardiac arrhythmia syndromes, Conduction disease, Inherited, Long QT syndrome type 3, Pharmacogenomics, Sodium channel",

author = "Smits, {Jeroen P.P.} and Blom, {Marieke T.} and Wilde, {Arthur A.M.} and Tan, {Hanno L.}",

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AU - Wilde, Arthur A.M.

AU - Tan, Hanno L.

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AB - Sodium (Na) channels are essential for cardiac electrical activity. Cardiac Na channel dysfunction, inherited or acquired, can induce life-threatening conduction and arrhythmia disorders. Inherited Na channel dysfunction may put affected patients at a greater risk for these complications when channel-modifying drugs are prescribed. This study addressed pharmacogenetic effects in three well-described Na channel-related diseases: long QT syndrome type 3, Brugada syndrome and inherited cardiac conduction disease. A review of the currently available literature on cardiac Na channel-modulating drugs was undertaken. An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms.

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Cardiac sodium channels and inherited electrophysiologic disorders: A pharmacogenetic overview

Abstract

Keywords

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