TY - JOUR
T1 - Carotid atherosclerosis in depression and anxiety: Associations for age of depression onset
AU - Seldenrijk, A.
AU - van Hout, H.P.J.
AU - van Marwijk, H.W.J.
AU - Groot, E.
AU - Gort, J.
AU - Rustemeijer, C.
AU - Diamant, M.
AU - Penninx, B.W.J.H.
PY - 2011
Y1 - 2011
N2 - Mental health and cardiovascular disease have been associated, whereas the temporal course and underlying mechanisms are still incompletely understood. Our aims were to examine the presence of subclinical atherosclerosis in subjects with depressive or anxiety disorder, also taking into account disorder characteristics (subtype, severity, duration, age of onset, medication). The sample included 470 depression or anxiety cases and 179 controls, aged 20-66 years, participating in the Netherlands Study of Depression and Anxiety (NESDA). Diagnoses were assigned using the DSM-IV based Composite International Diagnostic Interview. Carotid intima-media thickness (CIMT) and plaque information were obtained using B-mode ultrasound imaging. Overall, depressive and anxiety disorders were not associated with carotid atherosclerosis. However, age of depression onset was associated with CIMT (total: 0.01 mm per 10 years, P = 0.01; bifurcation: 0.02 mm per 10 years, P = 0.003) and plaque presence (OR = 1.35 per 10 years, 95%CI = 1.02-1.80, P = 0.04). When compared with controls, late-onset (≥ 40 years) depressed had an increased CIMT in the atherosclerosis progression-prone bifurcation segment (0.75 vs. 0.81 mm, P = 0.004). These findings suggest a distinct pathophysiology of late-onset as compared with early-onset depression, including a vascular component
AB - Mental health and cardiovascular disease have been associated, whereas the temporal course and underlying mechanisms are still incompletely understood. Our aims were to examine the presence of subclinical atherosclerosis in subjects with depressive or anxiety disorder, also taking into account disorder characteristics (subtype, severity, duration, age of onset, medication). The sample included 470 depression or anxiety cases and 179 controls, aged 20-66 years, participating in the Netherlands Study of Depression and Anxiety (NESDA). Diagnoses were assigned using the DSM-IV based Composite International Diagnostic Interview. Carotid intima-media thickness (CIMT) and plaque information were obtained using B-mode ultrasound imaging. Overall, depressive and anxiety disorders were not associated with carotid atherosclerosis. However, age of depression onset was associated with CIMT (total: 0.01 mm per 10 years, P = 0.01; bifurcation: 0.02 mm per 10 years, P = 0.003) and plaque presence (OR = 1.35 per 10 years, 95%CI = 1.02-1.80, P = 0.04). When compared with controls, late-onset (≥ 40 years) depressed had an increased CIMT in the atherosclerosis progression-prone bifurcation segment (0.75 vs. 0.81 mm, P = 0.004). These findings suggest a distinct pathophysiology of late-onset as compared with early-onset depression, including a vascular component
U2 - https://doi.org/10.3109/15622975.2011.583942
DO - https://doi.org/10.3109/15622975.2011.583942
M3 - Article
C2 - 21745125
SN - 1562-2975
VL - 12
SP - 549
EP - 558
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
IS - 7
ER -