CD27 is required for generation and long-term maintenance of T cell immunity

J. Hendriks, L. A. Gravestein, K. Tesselaar, R. A. van Lier, T. N. Schumacher, J. Borst

Research output: Contribution to journalArticleAcademicpeer-review

615 Citations (Scopus)

Abstract

The Traf-linked tumor necrosis factor receptor family member CD27 is known as a T cell costimulatory molecule. We generated CD27-/- mice and found that CD27 makes essential contributions to mature CD4+ and CD8+ T cell function: CD27 supported antigen-specific expansion (but not effector cell maturation) of naïve T cells, independent of the cell cycle-promoting activities of CD28 and interleukin 2. Primary CD4+ and CD8+ T cell responses to influenza virus were impaired in CD27-/- mice. Effects of deleting the gene encoding CD27 were most profound on T cell memory, reflected by delayed response kinetics and reduction of CD8+ virus-specific T cell numbers to the level seen in the primary response. This demonstrates the requirement for a costimulatory receptor in the generation of T cell memory
Original languageEnglish
Pages (from-to)433-440
JournalNature immunology
Volume1
Issue number5
DOIs
Publication statusPublished - 2000

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