TY - JOUR
T1 - CD47 in Erythrocyte Ageing and Clearance - the Dutch Point of View
AU - Burger, Patrick
AU - de Korte, Dirk
AU - van den Berg, Timo K
AU - van Bruggen, Robin
PY - 2012/10
Y1 - 2012/10
N2 - Recently, an important role for CD47, a well-known 'don't eat me' signal, in the clearance of aged erythrocytes was revealed. Experimental data support the conversion of CD47 from a 'don't eat me' to an 'eat me' signal through a conformational change in CD47. Intriguingly, erythrocyte phagocytosis after this switch seems to be mediated by the same receptor that normally signals inhibition of phagocytosis, SIRPα. In this review, the possible molecular mechanisms leading to this conformational change in CD47 as well as the possible signal transduction events leading to phagocytosis after this switch are discussed. Lastly, the consequences of this newly identified mode of erythrocyte phagocytosis for the clearance of aged erythrocytes during normal turnover and after erythrocyte transfusion are addressed.
AB - Recently, an important role for CD47, a well-known 'don't eat me' signal, in the clearance of aged erythrocytes was revealed. Experimental data support the conversion of CD47 from a 'don't eat me' to an 'eat me' signal through a conformational change in CD47. Intriguingly, erythrocyte phagocytosis after this switch seems to be mediated by the same receptor that normally signals inhibition of phagocytosis, SIRPα. In this review, the possible molecular mechanisms leading to this conformational change in CD47 as well as the possible signal transduction events leading to phagocytosis after this switch are discussed. Lastly, the consequences of this newly identified mode of erythrocyte phagocytosis for the clearance of aged erythrocytes during normal turnover and after erythrocyte transfusion are addressed.
U2 - https://doi.org/10.1159/000342231
DO - https://doi.org/10.1159/000342231
M3 - Article
C2 - 23801927
SN - 1660-3796
VL - 39
SP - 348
EP - 352
JO - Transfus. Med. Hemother.
JF - Transfus. Med. Hemother.
IS - 5
ER -