Abstract
Immunotherapy aimed at modulation of immune responses may serve as an important adjuvant to antibiotic therapy in the treatment of pneumonia. Alveolar macrophages and polymor-phonuclear cells play a prominent role in innate immunity in the lungs. These cells need to communicate in mounting an effective host defense against invading pathogens. Cytokines, chemokines, and colony-stimulating factors play a critical role in this process. Side-products of the coagulation cascade also enhance local inflammation. Activation of the complement system results in the formation of several proinflammatory mediators that can attract and activate polymorphonuclear cells, and formation of molecules with antimicrobial activity.
| Original language | English |
|---|---|
| Title of host publication | Principles of Molecular Medicine |
| Publisher | Humana Press |
| Pages | 912-919 |
| Number of pages | 8 |
| ISBN (Print) | 9781588292025 |
| DOIs | |
| Publication status | Published - 2006 |
Keywords
- Chemokines
- IL-10
- coagulation
- complement
- cytokines
- factor VII
- fibrinolysis
- granulocyte colony-stimulating factor
- plasminogen activator inhibitor-1
- pneumonia
- tissue factor
- tumor necrosis factor-α