Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

S.A. van de Pavert; B.J. Olivier; G. Goverse; M.F.R. Vondenhoff; M.J. Greuter; P. Beke; K. Kusser; U.E. Hopken; M. Lipp; K. Niederreither; R. Blomhoff; K. Sitnik; W.W. Agace; TD Randall; W. Jonge; R.E. Mebius; Uta E. Höpken; Troy D. Randall

doi:https://doi.org/10.1038/ni.1789

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

S.A. van de Pavert, B.J. Olivier, G. Goverse, M.F.R. Vondenhoff, M.J. Greuter, P. Beke, K. Kusser, U.E. Hopken, M. Lipp, K. Niederreither, R. Blomhoff, K. Sitnik, W.W. Agace, TD Randall, W. Jonge, R.E. Mebius, Uta E. Höpken, Troy D. Randall

Research output: Contribution to journal › Article › Academic › peer-review

243 Citations (Scopus)

Abstract

The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons

Original language	Undefined/Unknown
Pages (from-to)	1193-1U78
Journal	Nature immunology
Volume	10
Issue number	11
DOIs	https://doi.org/10.1038/ni.1789
Publication status	Published - 2009

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https://doi.org/10.1038/ni.1789

Cite this

van de Pavert, S. A., Olivier, B. J., Goverse, G., Vondenhoff, M. F. R., Greuter, M. J., Beke, P., Kusser, K., Hopken, U. E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W. W., Randall, TD., Jonge, W., Mebius, R. E., Höpken, U. E., & Randall, T. D. (2009). Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nature immunology, 10(11), 1193-1U78. https://doi.org/10.1038/ni.1789

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title = "Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation",

abstract = "The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons",

author = "{van de Pavert}, S.A. and B.J. Olivier and G. Goverse and M.F.R. Vondenhoff and M.J. Greuter and P. Beke and K. Kusser and U.E. Hopken and M. Lipp and K. Niederreither and R. Blomhoff and K. Sitnik and W.W. Agace and TD Randall and W. Jonge and R.E. Mebius and H{\"o}pken, {Uta E.} and Randall, {Troy D.}",

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doi = "https://doi.org/10.1038/ni.1789",

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van de Pavert, SA, Olivier, BJ, Goverse, G, Vondenhoff, MFR, Greuter, MJ, Beke, P, Kusser, K, Hopken, UE, Lipp, M, Niederreither, K, Blomhoff, R, Sitnik, K, Agace, WW, Randall, TD, Jonge, W , Mebius, RE, Höpken, UE & Randall, TD 2009, 'Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation', Nature immunology, vol. 10, no. 11, pp. 1193-1U78. https://doi.org/10.1038/ni.1789

TY - JOUR

T1 - Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

AU - van de Pavert, S.A.

AU - Olivier, B.J.

AU - Goverse, G.

AU - Vondenhoff, M.F.R.

AU - Greuter, M.J.

AU - Beke, P.

AU - Kusser, K.

AU - Hopken, U.E.

AU - Lipp, M.

AU - Niederreither, K.

AU - Blomhoff, R.

AU - Sitnik, K.

AU - Agace, W.W.

AU - Randall, TD

AU - Jonge, W.

AU - Mebius, R.E.

AU - Höpken, Uta E.

AU - Randall, Troy D.

PY - 2009

Y1 - 2009

N2 - The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons

AB - The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons

U2 - https://doi.org/10.1038/ni.1789

DO - https://doi.org/10.1038/ni.1789

M3 - Article

C2 - 19783990

SN - 1529-2908

VL - 10

SP - 1193-1U78

JO - Nature immunology

JF - Nature immunology

IS - 11

ER -