TY - JOUR
T1 - Chlamydia psittaci st24: Clonal strains of one health importance dominate in australian horse, bird and human infections
AU - Anstey, Susan I.
AU - Kasimov, Vasilli
AU - Jenkins, Cheryl
AU - Legione, Alistair
AU - Devlin, Joanne
AU - Amery-Gale, Jemima
AU - Gilkerson, James
AU - Hair, Sam
AU - Perkins, Nigel
AU - Peel, Alison J.
AU - Borel, Nicole
AU - Pannekoek, Yvonne
AU - Chaber, Anne-Lise
AU - Woolford, Lucy
AU - Timms, Peter
AU - Jelocnik, Martina
N1 - Funding Information: This research was funded by the Australian Research Council Discovery Early Career Research Award (DE190100238), awarded to M.J. We thank all the diagnostics laboratory teams from the University of Melbourne, NSW DPI and WA DPIRD for assisting us in sample collection and the USC Chlamydia team for their assistance during laboratory analyses. Funding Information: Funding: This research was funded by the Australian Research Council Discovery Early Career Research Award (DE190100238), awarded to M.J. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Chlamydia psittaci is traditionally regarded as a globally distributed avian pathogen that can cause zoonotic spill-over. Molecular research has identified an extended global host range and significant genetic diversity. However, Australia has reported a reduced host range (avian, horse, and human) with a dominance of clonal strains, denoted ST24. To better understand the widespread of this strain type in Australia, multilocus sequence typing (MLST) and ompA genotyping were applied on samples from a range of hosts (avian, equine, marsupial, and bovine) from Australia. MLST confirms that clonal ST24 strains dominate infections of Australian psittacine and equine hosts (82/88; 93.18%). However, this study also found novel hosts (Australian white ibis, King parrots, racing pigeon, bovine, and a wallaby) and demonstrated that strain diversity does exist in Australia. The discovery of a C. psittaci novel strain (ST306) in a novel host, the Western brush wallaby, is the first detection in a marsupial. Analysis of the results of this study applied a multidisciplinary approach regarding Chlamydia infections, equine infectious disease, ecology, and One Health. Recommendations include an update for the descriptive framework of C. psittaci disease and cell biology work to inform pathogenicity and complement molecular epidemiology.
AB - Chlamydia psittaci is traditionally regarded as a globally distributed avian pathogen that can cause zoonotic spill-over. Molecular research has identified an extended global host range and significant genetic diversity. However, Australia has reported a reduced host range (avian, horse, and human) with a dominance of clonal strains, denoted ST24. To better understand the widespread of this strain type in Australia, multilocus sequence typing (MLST) and ompA genotyping were applied on samples from a range of hosts (avian, equine, marsupial, and bovine) from Australia. MLST confirms that clonal ST24 strains dominate infections of Australian psittacine and equine hosts (82/88; 93.18%). However, this study also found novel hosts (Australian white ibis, King parrots, racing pigeon, bovine, and a wallaby) and demonstrated that strain diversity does exist in Australia. The discovery of a C. psittaci novel strain (ST306) in a novel host, the Western brush wallaby, is the first detection in a marsupial. Analysis of the results of this study applied a multidisciplinary approach regarding Chlamydia infections, equine infectious disease, ecology, and One Health. Recommendations include an update for the descriptive framework of C. psittaci disease and cell biology work to inform pathogenicity and complement molecular epidemiology.
KW - Australia
KW - Chlamydia psittaci
KW - Genetic diversity
KW - MLST
KW - Novel hosts
KW - Novel strains
KW - OmpA genotyping
UR - http://www.scopus.com/inward/record.url?scp=85113142921&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/pathogens10081015
DO - https://doi.org/10.3390/pathogens10081015
M3 - Article
C2 - 34451478
SN - 2076-0817
VL - 10
JO - Pathogens (Basel, Switzerland)
JF - Pathogens (Basel, Switzerland)
IS - 8
M1 - 1015
ER -