TY - JOUR
T1 - Cognitive phenotypes predict response to restorative cognitive rehabilitation in multiple sclerosis
AU - Ziccardi, Stefano
AU - Fuchs, Tom
AU - Dwyer, Michael G.
AU - Zivadinov, Robert
AU - Hulst, Hanneke E.
AU - Calabrese, Massimiliano
AU - Benedict, Ralph H. B.
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Background: Cognitive phenotyping may be useful for predicting rehabilitation response in multiple sclerosis. Objective: To evaluate the association between cognitive phenotype(s) and response to restorative cognitive rehabilitation (RRCR). Methods: In a post hoc retrospective analysis of the RRCR study including 51 multiple sclerosis patients, we evaluated both impairment within specific cognitive domains as well as overall global impairment severity to investigate their relationship to improvement following rehabilitation. Results: Greater improvement in executive function was predicted by impairment within this domain as well as by having fewer impaired cognitive domains overall. Similar results were observed for visuospatial memory. Conclusions: Patients most likely to benefit from restorative cognitive rehabilitation may exhibit impairment within the domain of interest yet lower cognitive burden overall.
AB - Background: Cognitive phenotyping may be useful for predicting rehabilitation response in multiple sclerosis. Objective: To evaluate the association between cognitive phenotype(s) and response to restorative cognitive rehabilitation (RRCR). Methods: In a post hoc retrospective analysis of the RRCR study including 51 multiple sclerosis patients, we evaluated both impairment within specific cognitive domains as well as overall global impairment severity to investigate their relationship to improvement following rehabilitation. Results: Greater improvement in executive function was predicted by impairment within this domain as well as by having fewer impaired cognitive domains overall. Similar results were observed for visuospatial memory. Conclusions: Patients most likely to benefit from restorative cognitive rehabilitation may exhibit impairment within the domain of interest yet lower cognitive burden overall.
KW - Cognitive phenotypes
KW - cognitive rehabilitation
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85178253526&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/37942544
U2 - 10.1177/13524585231208331
DO - 10.1177/13524585231208331
M3 - Article
C2 - 37942544
SN - 1352-4585
VL - 30
SP - 448
EP - 452
JO - MULTIPLE SCLEROSIS JOURNAL
JF - MULTIPLE SCLEROSIS JOURNAL
IS - 3
ER -